{
  "abstract": "Electrospun nanofibers (ESNFs) have become a major focus of modern research given their adaptable architecture, extensive interface, and distinctive physicochemical characteristics, making them appropriate for varied applications such as catalysis and environmental cleanup, drug delivery (DD), tissue engineering (TE), sensing, actuation, and various energy-related technologies. As a result, electrospinning (ES) has emerged as a versatile manufacturing technique, driving intensive efforts to engineer nanofibrous structures specifically for biomedical purposes. Functionalization of ESNFs can be achieved by embedding functional agents or altering surface chemistry to introduce specific functionalities. This review discusses the fabrication methods, optimization techniques, and broad biomedical applications of modified ESNFs, emphasizing their key properties, including biocompatibility, degradability, and safety profile. The article outlines various strategies for creating and modifying ESNFs, followed by a comprehensive analysis of their applications in tissue regeneration, DD, wound repair, antimicrobial therapy, cancer diagnostics and treatment, and biosensing. By critically evaluating recent advances, highlighting future directions, and addressing ongoing challenges about ES, this review underscores the transformative potential of functionalized ESNFs as efficient and adaptable biomaterials for biomedical technologies.",
  "abstract_shown": true,
  "affiliations": [
    "New Technologies Research Centre, University of West Bohemia in Pilsen, 30100, Pilsen, Czech Republic; Corresponding author.",
    "Department of Physical Sciences, Kristu Jayanti (Deemed to be University), Bangalore, 560077, Karnataka, India; Corresponding author.",
    "Department of Biochemistry, Faculty of Science, Ege University, Izmir, 35100, Türkiye",
    "New Technologies Research Centre, University of West Bohemia in Pilsen, 30100, Pilsen, Czech Republic; Department of Material Science and Metallurgy, Faculty of Mechanical Engineering, University of West Bohemia in Pilsen, 30100, Pilsen, Czech Republic",
    "Institute of Pharmaceutical Sciences, Faculty of Medicine, KUL-The John Paul II Catholic University of Lublin, 20708, Poland",
    "School of Mechanical Engineering, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Patia, Bhubaneswar, Odisha, 751024, India",
    "Department of Chemistry, Krishna School of Science, Drs. Kiran and Pallavi Patel Global University (KPGU), Varnama, Vadodara, Gujarat, 391243, India",
    "Department of Chemical Sciences, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India",
    "Department of Mechanical Engineering, Synergy Institute of Engineering and Technology, Dhenkanal, Odisha, 759001, India"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kalim Deshmukh"
    },
    {
      "affs": [
        1
      ],
      "name": "Mayank Pandey"
    },
    {
      "affs": [
        2
      ],
      "name": "Hichem Moulahoum"
    },
    {
      "affs": [
        2
      ],
      "name": "Faezeh Ghorbanizamani"
    },
    {
      "affs": [
        3
      ],
      "name": "Tomáš Kovářík"
    },
    {
      "affs": [
        4
      ],
      "name": "Agata Przekora-Kuśmierz"
    },
    {
      "affs": [
        5
      ],
      "name": "Hemalata Jena"
    },
    {
      "affs": [
        6
      ],
      "name": "Miral Vora"
    },
    {
      "affs": [
        7
      ],
      "name": "Gautam Patel"
    },
    {
      "affs": [
        8
      ],
      "name": "Priyabrat Pradhan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cbfjpwxdqnhds.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bioactmat.2026.10.009",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2452199X26005918",
  "id": "cbfjpwxdqnhds",
  "issns": [
    "2452-199X"
  ],
  "landing_url": "https://doi.org/10.1016/j.bioactmat.2026.10.009",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "TA401-492"
    ],
    [
      "openalex",
      "2502|Electrospun Nanofibers in Biomedical Applications"
    ]
  ],
  "openalex": "W7223197173",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718865/pdf/?tool=EBI",
  "pmcid": "PMC13718865",
  "pmid": "42960302",
  "published": "2026-10-22",
  "publisher": "KeAi Communications Co., Ltd.",
  "ris": "https://research.draconitic.com/paper/cbfjpwxdqnhds.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:42Z",
      "native_id": "7f4e5a486f0b4d22b5c0a0d7ab85fcb5",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.bioactmat.2026.10.009"
    },
    {
      "first_seen": "2026-10-31T00:20:38Z",
      "native_id": "PMC:PMC13718865",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718865"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42960302",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960302"
    },
    {
      "first_seen": "2026-11-02T12:22:48Z",
      "native_id": "PMC13718865",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bioactmat.2026.10.009"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Electrospun Nanofibers in Biomedical Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Recent advances in functionalized electrospun nanofibers for biomedical and therapeutic applications: A comprehensive review",
  "title_text": "Recent advances in functionalized electrospun nanofibers for biomedical and therapeutic applications: A comprehensive review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:48Z",
  "url": "https://research.draconitic.com/paper/cbfjpwxdqnhds",
  "venue": "Bioactive Materials",
  "versions": []
}