{
  "abstract": "OBJECTIVES: This study aimed to evaluate the safety and efficacy of teclistamab, a T cell-redirecting bispecific antibody targeting B-cell maturation antigen, in a case series of severe autoimmune diseases. METHODS: Data were retrospectively collected from patients with treatment-refractory systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIMs), systemic lupus erythematosus (SLE), undifferentiated connective tissue disease (UCTD), or IgG4-related disease (IgG4-RD) who received 1 cycle of teclistamab at 5 European centres. RESULTS: Eighteen patients (72% women, median age 48.5 years, 10 SSc, 4 IIM, 2 SLE, 1 UCTD, and 1 IgG4-RD) with a median of 5 prior therapies and a median cumulative dose of 6.36 mg/kg teclistamab were included. The median follow-up was 5.1 months (range, 0.8-21.2 months). A total of 22 cytokine release syndrome episodes (16 grade 1 and 6 grade 2) occurred in 12 patients (67%). All patients developed severe hypogammaglobulinaemia, and 5 (28%) experienced severe infections. Two patients developed an inflammatory bowel disease-like colitis. Two patients with severe SSc-associated cardiac involvement died, 1 due to sudden cardiac death and the other following diffuse alveolar haemorrhage and heart failure. B-cell depletion was observed in all patients, accompanied by significant reductions in autoantibody levels. Teclistamab was associated with major clinical responses in 11 (61%) and minimal-to-moderate responses in 4 (22%) patients, despite discontinuation of immunosuppressive therapy. CONCLUSIONS: Teclistamab demonstrated the potential to induce treatment-free responses in refractory autoimmune disease, but clinically relevant safety events, including infections and fatal outcomes in patients with advanced cardiac involvement, highlight the need for careful patient selection and monitoring.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, c/o Charité - Universitätsmedizin Berlin, Berlin, Germany",
    "Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
    "Institute of Clinical Pharmacology and Toxicology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
    "Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, Berlin, Germany",
    "Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Rheumatology and Clinical Immunology, Immanuel Krankenhaus, Berlin, Germany",
    "Faculty of Medicine and Dentistry, University La Sapienza, Rome, Italy",
    "Department of Immunology, Labor Berlin - Charité Vivantes GmbH, Berlin, Germany",
    "Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany",
    "Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; ImmunoPreCept Cluster, Berlin, Germany; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany",
    "Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany",
    "Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Hematology and Oncology, Universitätsmedizin Greifswald, Greifswald, Germany",
    "Division of Rheumatology and Systemic Inflammatory Diseases, III, Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany",
    "Division of Rheumatology, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany",
    "Division of Rheumatology, Department of Internal Medicine II (Haematology, Oncology, Clinical Immunology and Rheumatology), University Hospital Tübingen, Tübingen, Germany",
    "Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark",
    "Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark",
    "Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, c/o Charité - Universitätsmedizin Berlin, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, Berlin, Germany; ImmunoPreCept Cluster, Berlin, Germany",
    "Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, c/o Charité - Universitätsmedizin Berlin, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, Berlin, Germany. Electronic address: david.simon@charite.de"
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  "article_type": null,
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      "name": "Marie Luise Hütter‐Krönke",
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      "name": "Frank Buttgereit",
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      "name": "Ulrich Bernd Keller",
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      "name": "Antonia Busse",
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      "name": "Jan Krönke",
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      "name": "Ina Kötter",
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      "name": "Phillip Kremer",
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      "name": "Tarik Exner",
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      "name": "Ann‐Christin Pecher",
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      "name": "Dorothee Kaudewitz",
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      "name": "Klaus Henrik Søndergaard",
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      "name": "Anne Troldborg",
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      "name": "Jörg C. Henes",
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      "name": "Hanns‐Martin Lorenz",
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      "name": "Isabell Haase",
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      "name": "Martin Krusche",
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      "name": "Gerhard Krönke",
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      "name": "David Simón",
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      "name": "Tobias Alexander",
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  "bibtex": "https://research.draconitic.com/paper/cbyab17ag456z.bib",
  "cited_by": 10,
  "doi": "10.1016/j.ard.2026.05.021",
  "fulltext_url": null,
  "id": "cbyab17ag456z",
  "issns": [
    "0003-4967",
    "1468-2060"
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  "landing_url": "https://doi.org/10.1016/j.ard.2026.05.021",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2734|Systemic Sclerosis and Related Diseases"
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  "openalex": "W7165380255",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42321107",
  "published": "2026-06-01",
  "publisher": "BMJ",
  "ris": "https://research.draconitic.com/paper/cbyab17ag456z.ris",
  "sources": [
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      "first_seen": "2026-10-30T13:26:56Z",
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  "subjects": [
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      "field": "medicine",
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  "title": "Teclistamab for treatment-refractory autoimmune diseases: a multicentre case series",
  "title_text": "Teclistamab for treatment-refractory autoimmune diseases: a multicentre case series",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T13:20:39Z",
  "url": "https://research.draconitic.com/paper/cbyab17ag456z",
  "venue": "Annals of the Rheumatic Diseases",
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