{
  "abstract": "This study reports the synthesis of a novel deep eutectic solvent (DES), [DABCO][Imi]₂, for the multicomponent synthesis of 2-oxo-4,6-disubstituted-1,2-dihydropyridine-3-carbonitrile derivatives. A novel DES was successfully synthesized and structurally characterized using ¹H NMR, ¹³C NMR, FT-IR spectroscopy, and thermogravimetric analysis (TGA). A series of 30 derivatives was synthesized in moderate isolated yields (up to 40%). The synthesized compounds were evaluated for their inhibitory activity against human melanoma A375 cancer cells. Among the synthesized compounds, (5cg) and (5ch) exhibited the highest antiproliferative activity against A375 cells, with IC₅₀ values of 17.44 ± 0.09 mM and 12.04 ± 0.12 mM, respectively. Molecular docking suggested that SIRT1 may serve as a potential molecular target for these compounds. Molecular docking and ADME prediction suggested that these compounds possess acceptable drug-like properties and may serve as suitable starting points for further structural optimization.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Organic Chemistry, Faculty of Chemistry, University of Science Ho Chi Minh City 700000 Vietnam ngthai@hcmus.edu.vn.",
    "Vietnam National University Ho Chi Minh City 700000 Vietnam."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Truong-Thinh Huy Pham"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tuan-Anh Ngoc Tran",
      "orcid": "0009-0000-4935-3454"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Dat Minh Tran"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huy-Hoang Le Nguyen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hai Truong Nguyen",
      "orcid": "0000-0002-9865-9051"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cckz3n82cxhyy.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06973h",
  "fulltext_url": "https://europepmc.org/articles/PMC13688107",
  "id": "cckz3n82cxhyy",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923875",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Multicomponent Synthesis of Heterocycles"
    ]
  ],
  "openalex": "W7223186946",
  "pdf_url": "https://europepmc.org/articles/PMC13688107?pdf=render",
  "pmcid": "PMC13688107",
  "pmid": "42923875",
  "published": "2026-10-22",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/cckz3n82cxhyy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923875",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923875"
    },
    {
      "first_seen": "2026-11-07T12:23:38Z",
      "native_id": "PMC13688107",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra06973h"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Multicomponent Synthesis of Heterocycles",
      "subfield": "organic"
    }
  ],
  "title": "A recyclable [DABCO][Imi]₂ deep eutectic solvent for multicomponent synthesis of 1,2-dihydropyridine-3-carbonitriles: in vitro antiproliferative and in silico molecular evaluation.",
  "title_text": "A recyclable [DABCO][Imi]₂ deep eutectic solvent for multicomponent synthesis of 1,2-dihydropyridine-3-carbonitriles: in vitro antiproliferative and in silico molecular evaluation.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:06Z",
  "url": "https://research.draconitic.com/paper/cckz3n82cxhyy",
  "venue": "RSC advances",
  "versions": []
}