{
  "abstract": "Conventional imaging poorly captures bone disorganization, a pathological feature of hypophosphatasia (HPP). This single-patient case report applied ALIGNOGRAM to previously published open-access distal radius radiographs from a 16-year-old with severe HPP before and after six months of asfotase alfa. It detected overt, subtle, and covert lesions and quantified reduced lesion burden post-treatment. Residual disorganization persisted. These findings support preliminary technical feasibility, with independent validation in larger prospective cohorts required to establish diagnostic and treatment-response validity.",
  "abstract_shown": true,
  "affiliations": [
    "Monash University School of Clinical Sciences at Monash Health, Clayton, Victoria, Australia",
    "Austin Health, Heidelberg, Victoria, Australia",
    "Division of Endocrinology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Simon Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Cat Shore-Lorenti"
    },
    {
      "affs": [
        1
      ],
      "name": "Cherie Chiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Frances Milat"
    },
    {
      "affs": [
        2
      ],
      "name": "Peter R. Ebeling"
    },
    {
      "affs": [
        0
      ],
      "name": "Roger Zebaze"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ccrxmnwtj3mnj.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bonr.2026.101963",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722107/?tool=EBI",
  "id": "ccrxmnwtj3mnj",
  "issns": [
    "2352-1872"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13722107",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2712|Alkaline Phosphatase Research Studies"
    ]
  ],
  "openalex": "W7223268519",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722107/pdf/?tool=EBI",
  "pmcid": "PMC13722107",
  "pmid": "42965176",
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/ccrxmnwtj3mnj.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13722107",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722107"
    },
    {
      "first_seen": "2026-11-03T12:22:40Z",
      "native_id": "PMC13722107",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bonr.2026.101963"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Alkaline Phosphatase Research Studies",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Automated detection and quantification of bone disorganization in hypophosphatasia before and after asfotase alfa: A case report",
  "title_text": "Automated detection and quantification of bone disorganization in hypophosphatasia before and after asfotase alfa: A case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:40Z",
  "url": "https://research.draconitic.com/paper/ccrxmnwtj3mnj",
  "venue": "Bone reports",
  "versions": []
}