{
  "abstract": "Human B cell differentiation into antibody-secreting plasma cells (PCs) requires coordinated transcriptional and organelle remodeling. Using single-cell transcriptomics in an in vitro human B cell differentiation system, we identified a Day-8 commitment checkpoint separating PC, memory B cell, and germinal center-like trajectories and defined an XBP1-associated transcriptional program linked to organelle remodeling. Within this program, CAV1 was induced during PC commitment and encoded a non-caveolar Cav-1β isoform expressed in plasmablasts and PCs. Proteomic analyses showed that Cav-1β associates with endoplasmic reticulum, secretory, and nutrient-sensing proteins, including components of the V-ATPase-RAGulator-RAG complex. CAV1 silencing had modest effects on PC differentiation but did not alter acute mTORC1 activation or antibody secretion. These findings place Cav-1β within the membrane and organelle remodeling program of human PCs and highlight how intracellular architecture may be coupled to metabolic and secretory adaptation during plasma cell differentiation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "name": "Gersende Caron"
    },
    {
      "name": "Fabienne Desmots"
    },
    {
      "name": "Mélanie Chabaud"
    },
    {
      "name": "Maud Lemarié"
    },
    {
      "name": "Vincent Olivier"
    },
    {
      "name": "Fabrice Chatonnet"
    },
    {
      "name": "Céline Nonn"
    },
    {
      "name": "Cassandra Jadeau"
    },
    {
      "name": "Simon Léonard"
    },
    {
      "name": "Céline Monvoisin"
    },
    {
      "name": "Kathleen Santamaria"
    },
    {
      "name": "Cédric M. Blouin"
    },
    {
      "name": "Noudjoud Attaf"
    },
    {
      "name": "Tarek Gharsalli"
    },
    {
      "name": "Pierre Milpied"
    },
    {
      "name": "Christophe Lamaze"
    },
    {
      "name": "Céline Pangault"
    },
    {
      "name": "Marion Haas"
    },
    {
      "name": "Thierry Fest",
      "orcid": "0000-0002-6437-4189"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ccwp15np99w61.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117865",
  "fulltext_url": "https://europepmc.org/articles/PMC13682384",
  "id": "ccwp15np99w61",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03248-7",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cell biology"
    ],
    [
      "heading",
      "Functional aspects of cell biology"
    ],
    [
      "heading",
      "Integrative aspects of cell biology"
    ],
    [
      "heading",
      "Organizational aspects of cell biology"
    ],
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7221627351",
  "pdf_url": "https://europepmc.org/articles/PMC13682384?pdf=render",
  "pmcid": "PMC13682384",
  "pmid": "42904179",
  "published": "2026-10-13",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/ccwp15np99w61.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117865",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03248-7"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117865",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032487"
    },
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42904179",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42904179"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "Single-cell mapping of human plasma cell fate reveals a commitment checkpoint and Cav-1β expression associated with mTORC1 machinery",
  "title_text": "Single-cell mapping of human plasma cell fate reveals a commitment checkpoint and Cav-1β expression associated with mTORC1 machinery",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/ccwp15np99w61",
  "venue": "iScience",
  "versions": []
}