{
  "abstract": "Objectives: Gross tumour volume has been proposed as a complementary prognostic marker in laryngeal squamous cell carcinoma. This systematic review and meta-analysis evaluates the prognostic value of pre-treatment gross tumour volume.\n\nMethods: MEDLINE, Embase and Scopus were systematically searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies reporting pre-treatment gross tumour volume and survival outcomes in laryngeal cancer were included. The primary outcome was overall survival, and the secondary outcome was disease-free survival. Hazard ratios were pooled using random-effects meta-analysis. Risk of bias was assessed using the Quality in Prognosis Studies tool, and certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach.\n\nResults: Eight retrospective studies including 1351 patients were included. Increasing gross tumour volume was significantly associated with worse overall survival (pooled hazard ratio per 1 cm3 increase: 1.03; 95 per cent confidence interval: 1.02–1.05), with a similar association observed for disease-free survival. Overall risk of bias was moderate.\n\nConclusions: Higher gross tumour volume is independently associated with poorer survival in laryngeal cancer and may provide prognostic information beyond tumour-node-metastasis staging.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology - Head & Neck Surgery, University of California San Diego, USA",
    "Calderdale and Huddersfield NHS Foundation Trust, UK",
    "Macquarie University Hospital, Australia",
    "Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, UK"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shahid Iqbal",
      "orcid": "0000-0001-5119-3576"
    },
    {
      "affs": [
        1
      ],
      "name": "Saad Illahi"
    },
    {
      "affs": [
        2
      ],
      "name": "Rumail Zaheer"
    },
    {
      "affs": [
        3
      ],
      "name": "Ashir Iqbal"
    },
    {
      "affs": [
        0
      ],
      "name": "Ely Cheikh Boussaty"
    },
    {
      "affs": [
        0
      ],
      "name": "Charles S. Coffey"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cd0a1sd9sj93d.bib",
  "cited_by": 1,
  "doi": "10.1017/s0022215126105313",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735502/",
  "id": "cd0a1sd9sj93d",
  "issns": [
    "0022-2151",
    "1748-5460"
  ],
  "landing_url": "https://doi.org/10.1017/s0022215126105313",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7167037011",
  "pdf_url": "https://www.cambridge.org/core/services/aop-cambridge-core/content/view/86A7484920679440C7331D485DD4A720/S0022215126105313a.pdf/div-class-title-prognostic-value-of-gross-tumour-volume-in-laryngeal-cancer-a-systematic-review-and-meta-analysis-div.pdf",
  "pmcid": "PMC13735502",
  "pmid": "42388132",
  "published": "2026-11-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cd0a1sd9sj93d.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:10Z",
      "native_id": "PMC13735502",
      "source": "pmc",
      "url": "https://doi.org/10.1017/s0022215126105313"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis",
  "title_text": "Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:10Z",
  "url": "https://research.draconitic.com/paper/cd0a1sd9sj93d",
  "venue": "The Journal of Laryngology and Otology",
  "versions": []
}