{
  "abstract": "Much remains unknown about cholera transmission dynamics in Africa. Applying both traditional phylogeographic techniques and innovative methods for combining epidemiologic and genomic data, we identified three to four distinct “cholera transmission units” within which cross-border cholera transmission has been more frequent. These units can be grouped into two major transmission clusters, one in Western Africa and bordering countries and one spanning the Central, Eastern, and Southern regions. Simulation studies show that these clusters can be used to assess the risk of international spread of introduced cholera strains and identify heterogeneities in the speed of international spread based on outbreak location. Our methods further allow us to infer cholera incidence attributable to specific lineages in the absence of sequencing data. This work has clear implications for cholera control.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
    "Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.",
    "Geneva Centre for Emerging Viruses and Division of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland.",
    "Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.",
    "Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bethany L. DiPrete",
      "orcid": "0000-0003-1298-4433"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Javier Perez-Saez",
      "orcid": "0000-0003-3909-2048"
    },
    {
      "affs": [
        3
      ],
      "name": "Shirlee Wohl",
      "orcid": "0000-0002-0311-3348"
    },
    {
      "affs": [
        3
      ],
      "name": "Nathaniel Matteson",
      "orcid": "0009-0007-0511-759X"
    },
    {
      "affs": [
        0
      ],
      "name": "Seungwon Kim",
      "orcid": "0000-0002-5509-0969"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Andrew S. Azman",
      "orcid": "0000-0001-8662-9077"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Justin Lessler",
      "orcid": "0000-0002-9741-8109"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cd0r9m7gqzf0b.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aeb4683",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733893/",
  "id": "cd0r9m7gqzf0b",
  "issns": [
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  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
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  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Epidemiology"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "heading",
      "SciAdv r-articles"
    ],
    [
      "heading",
      "Social and Interdisciplinary Sciences and Public Health"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": "PMC13733893",
  "pmid": "42981420",
  "published": "2026-11-04",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/cd0r9m7gqzf0b.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T00:20:34Z",
      "native_id": "10.1126/sciadv.aeb4683",
      "source": "feed-science",
      "url": "https://www.science.org/doi/abs/10.1126/sciadv.aeb4683"
    },
    {
      "first_seen": "2026-11-05T00:20:35Z",
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      "url": "https://www.science.org/doi/10.1126/sciadv.aeb4683"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Epidemiology",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Defining epidemiologically relevant units of cholera transmission in sub-Saharan Africa",
  "title_text": "Defining epidemiologically relevant units of cholera transmission in sub-Saharan Africa",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:34Z",
  "url": "https://research.draconitic.com/paper/cd0r9m7gqzf0b",
  "venue": "Science Advances",
  "versions": []
}