{
  "abstract": "A fundamental question in systems neuroscience is how the brain's excitation-inhibition (E/I) balance shapes the temporal structure of neural activity and whether we can non-invasively recover this relationship from neural scaling properties. We show that MRS-derived E/I balance is expressed in long-range temporal dynamics and constrained by cytoarchitecture. The laminar organisation of inhibitory circuits, spanning agranular to granular cortex, determines how faithfully regional dynamics reflect E/I balance. This neurochemical signature is state-dependent: its relationship with cortical dynamics reverses during task engagement, consistent with traversal of dynamical regimes around a critical point. It extends beyond fMRI to arousal-linked dynamics, indexed by pupil diameter and microsaccades, indicating a global mode of cortical state rather than a regionally isolated property. The imprint of E/I balance on long-range dynamics follows the sensory-association axis at rest, and is reconfigured during task engagement. These findings establish E/I balance as a neurochemical quantity with structured, scalable signatures across the temporal and spatial organization of the human cortex.",
  "abstract_shown": true,
  "affiliations": [
    "Ecole Polytechnique Federale de Lausanne"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "M. Bisi"
    },
    {
      "name": "A. Ferrari"
    },
    {
      "name": "J. K. Degutis"
    },
    {
      "name": "S. Tambalo"
    },
    {
      "name": "A. I. Renton"
    },
    {
      "name": "M. V. Lombardo"
    },
    {
      "name": "J. Jovicich"
    },
    {
      "name": "D. Van De Ville"
    },
    {
      "affs": [
        0
      ],
      "name": "F. Saviola"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cd1t3myq1g1hq.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.30.763069",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763069v1.full",
  "id": "cd1t3myq1g1hq",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763069v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763069v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cd1t3myq1g1hq.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:20:59Z",
      "native_id": "10.64898/2026.10.30.763069",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763069v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Cortical long-range dynamics track excitation-inhibition balance across cognitive states and organizational principles",
  "title_text": "Cortical long-range dynamics track excitation-inhibition balance across cognitive states and organizational principles",
  "type": "preprint",
  "updated_at": "2026-11-03T00:20:21Z",
  "url": "https://research.draconitic.com/paper/cd1t3myq1g1hq",
  "venue": "bioRxiv",
  "versions": []
}