{
  "abstract": "In networked dynamical systems, the parameter of primary mechanistic interest is signed interaction structure. Recovering this structure from perturbation time-series data is a fundamental identification problem, compounded by three coupled obstacles: the combinatorial complexity of interaction architectures, ambiguity of causal attribution under limited interventions, and state-dependent dynamics that confound structural inference. Each obstacle is structural in origin and calls for a structural solution. We address these challenges by adopting a reductionist approach, introducing Fundamental Dynamical Units (FDUs): signed three-node interaction patterns as composable primitives that convert the interaction hypothesis space into a finite, constructive, and tractable representation. We show that local interaction structure determines the perturbation conditions required to disentangle direct from relayed influence, making intervention design a structural consequence of the FDU representation. We embed FDU-regularized structural inference within a physics-informed neural ordinary differential equation (ODE) whose governing-equation constraint transforms structural hypotheses into verifiable dynamical predictions, enabling joint recovery of interaction structure and perturbation-resolved trajectories. Validated on synthetic benchmarks with known ground truth, the framework supports structural commitment, expressed through FDU primitives, motif-prescribed intervention design, and physics-informed learning, as a principled basis for mechanistically interpretable inference in networked dynamical systems.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Nima Nouri"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cdpx4jywzpjyg.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-73479-7",
  "fulltext_url": null,
  "id": "cdpx4jywzpjyg",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-73479-7",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gene Regulatory Network Analysis"
    ]
  ],
  "openalex": "W7162311715",
  "pdf_url": "https://www.nature.com/articles/s41598-026-73479-7_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/cdpx4jywzpjyg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.1038/s41598-026-73479-7",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-73479-7"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gene Regulatory Network Analysis",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Fundamental dynamical units for physics-informed structural inference from perturbation time-series in networked systems",
  "title_text": "Fundamental dynamical units for physics-informed structural inference from perturbation time-series in networked systems",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/cdpx4jywzpjyg",
  "venue": "Scientific Reports",
  "versions": []
}