{
  "abstract": "Background: Psoriasis is a systemic inflammatory disorder associated with cardiovascular comorbidities. Although an association between psoriasis and coronary heart disease (CHD) has been established, data from southern Chinese populations remain limited. Objective: The purpose was to examine the factors associated with CHD in patients with psoriasis in a southern Chinese population. Methods: We conducted a multicenter, retrospective case–control study across three hospitals. This study included 56 cases (psoriasis with CHD) and 112 age-matched controls (psoriasis without CHD). The data were obtained from a pre-established psoriasis-specific database (September 2023–February 2025). Univariate analysis used binary logistic regression; multivariable conditional logistic regression accounted for the 1:2 age-matched design, with sex and smoking forced into the model. Results: In the multivariable conditional logistic regression analysis, greater body surface area (BSA) involvement (OR = 1.034, 95% CI: 1.009–1.059, p = 0.007), diabetes (OR = 4.748, 95% CI: 1.490–15.132, p = 0.008), and dyslipidemia (OR = 33.869, 95% CI: 4.549–252.136, p < 0.001) were significantly associated with CHD. Hypertension and smoking showed positive but non-significant associations. Conclusions: Greater BSA involvement, diabetes, and dyslipidemia were associated with CHD in this southern Chinese psoriasis cohort, consistent with previous international cohorts. These associations should be interpreted as cross-sectional rather than causal.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China",
    "Division of Dermatology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China",
    "Division of Dermatology, Department of Medicine, Queen Mary Hospital, Hong Kong, China",
    "Department of Dermatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuying Yao"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Martin Man Ho Chung",
      "orcid": "0009-0008-9420-4667"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhengfeng Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Lan"
    },
    {
      "affs": [
        0
      ],
      "name": "Shaozhen Mai"
    },
    {
      "affs": [
        0
      ],
      "name": "Liuyu Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiaoyan Wu"
    },
    {
      "affs": [
        3
      ],
      "name": "Yu Zhang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Christina Sze Man Wong",
      "orcid": "0000-0003-4603-6407"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhenying Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cdt9s1rj1dvew.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218384",
  "fulltext_url": null,
  "id": "cdt9s1rj1dvew",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8384",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
    ]
  ],
  "openalex": "W7224134930",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/cdt9s1rj1dvew.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218384",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8384"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Psoriasis: Treatment and Pathogenesis",
      "subfield": "immunology"
    }
  ],
  "title": "Regional Validation of Coronary Heart Disease Risk Factors in Psoriasis: A Multicenter Study in Southern China",
  "title_text": "Regional Validation of Coronary Heart Disease Risk Factors in Psoriasis: A Multicenter Study in Southern China",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/cdt9s1rj1dvew",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}