{
  "abstract": "Hyperpolarized 13 C-MRI enables real-time imaging of metabolic conversions in vivo, but remains largely restricted to specialized sites with superconducting high-field MRI and polarization infrastructure. Here we present a broadly deployable method for preclinical hyperpolarized 13 C-metabolic imaging, which combines signal amplification by reversible exchange (SABRE), a parahydrogen-based hyperpolarization technique, with detection of [1- 13 C]pyruvate-d 3 in a compact 436 mT permanent-magnet small-animal MRI system. SABRE yields 13 C-pyruvate polarization of 13% at ~30 mM in a purified, biocompatible solution, with a T 1 relaxation time of 140 s. In a transgenic breast cancer mouse model, 13 C-chemical shift imaging after injection resolves pyruvate, pyruvate hydrate and lactate in vivo, maps elevated lactate-to-pyruvate ratios in mammary tumors and images three freshly prepared pyruvate doses sequentially in the same animal in less than one hour. This compact SABRE-to-low-field method makes repeated hyperpolarized 13 C-metabolic imaging mobile and accessible in standard preclinical research environments.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany",
    "German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany",
    "University of Freiburg, Faculty of Biology, Freiburg, Germany",
    "Institute for Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany",
    "Scientific Workshop, Department of Neurology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany",
    "NVision Quantum Technologies GmbH, Ulm, Germany",
    "Department of Cardiology and Angiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany",
    "Laboratory of Engineering, Informatics and Imaging (ICube), Integrative Multimodal Imaging in Healthcare (IMIS) research team, CNRS, UMR 7357, University of Strasbourg, Strasbourg, France",
    "Biophysics and Nuclear Medicine, Strasbourg University Hospitals, Strasbourg, France",
    "Federation of Translational Medicine of Strasbourg (FMTS), Faculty of Medicine, Strasbourg University, Strasbourg, France",
    "Section Biomedical Imaging (SBMI), Molecular Imaging North Competence Center (MOINCC), Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany",
    "Pure Devices GmbH, Rimpar, Germany",
    "Department of Physics and Astronomy, Ruprecht-Karls University Heidelberg, Heidelberg, Germany",
    "German Cancer Research Center (DKFZ), Heidelberg, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Josef Elsasser",
      "orcid": "0009-0000-5431-6535"
    },
    {
      "affs": [
        0
      ],
      "name": "Stefan Sell"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Philipp Groß"
    },
    {
      "affs": [
        0
      ],
      "name": "Moritz Weigt"
    },
    {
      "affs": [
        0
      ],
      "name": "Zirun Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Lisa Heß"
    },
    {
      "affs": [
        4
      ],
      "name": "Gerd Strohmeier"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Behnam Shamshiri"
    },
    {
      "affs": [
        0
      ],
      "name": "Henri de Maissin"
    },
    {
      "affs": [
        5
      ],
      "name": "Sebastian Lucas"
    },
    {
      "affs": [
        6
      ],
      "name": "Alexander Maier"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Laura Harsan"
    },
    {
      "affs": [
        7,
        8,
        9
      ],
      "name": "Caroline Bund"
    },
    {
      "affs": [
        10
      ],
      "name": "Jan-Bernd Hövener"
    },
    {
      "affs": [
        0
      ],
      "name": "Maxim Zaitsev"
    },
    {
      "affs": [
        11
      ],
      "name": "Markus Mützel"
    },
    {
      "affs": [
        11
      ],
      "name": "Michael Distler"
    },
    {
      "affs": [
        11
      ],
      "name": "Toni Driessle"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Leif Schröder"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Thomas Reinheckel"
    },
    {
      "affs": [
        0
      ],
      "name": "Martin Pichotka"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Andreas B. Schmidt"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ce1w9jn12axv5.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010524/v1",
  "fulltext_url": null,
  "id": "ce1w9jn12axv5",
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  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010524/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1607|Advanced NMR Techniques and Applications"
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  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010524/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/ce1w9jn12axv5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010524",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010524/v2"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Advanced NMR Techniques and Applications",
      "subfield": "physical"
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  ],
  "title": "A Broadly Deployable Method for Repeated Hyperpolarized ¹³ C Metabolic Imaging in Living Animals",
  "title_text": "A Broadly Deployable Method for Repeated Hyperpolarized ¹³ C Metabolic Imaging in Living Animals",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/ce1w9jn12axv5",
  "venue": "ChemRxiv",
  "versions": []
}