{
  "abstract": "Aims\n\nVarious clinical risk factors impact the natural history of Brugada syndrome (BrS) and establish the basis of current clinical practice guidelines (CPG) indications for implantable cardioverter-defibrillator (ICD). Due to the time-dependent expressivity of BrS, their performance in predicting the actual occurrence of arrhythmic events after ICD implantation remains unknown.Objectives\n\nTo assess the occurrence of arrhythmic events based on the CPG indications and whether the genetic substrate can add to the prediction of arrhythmic events at follow-up.Methods and results\n\nWe enrolled consecutive patients who underwent ICD implant either for primary or secondary prevention. Prospective clinical data included arrhythmic history, electrocardiographic findings, therapies, SCN5A gene mutations, and genotyping of three BrS-associated single nucleotide variants. Eleven per cent of 551 patients experienced life-threatening arrhythmic events (LAE) over a median follow-up of 8.1 years. Patients with ESC class IIA indication had a similar risk profile as those implanted for secondary prevention. The recently developed BrS 5-year risk score, including clinical and genetic variables, was a determinant of outcome in the whole cohort and in patients implanted for primary prevention: 26.93 ± 3.33 vs. 4.41 ± 0.61 and 11.67 ± 1.52 vs. 5.36 ± 0.99 in patients with LAEs compared with those without events (P < 0.0001).Conclusion\n\nCPG class IIa and I had a similar rate of ICD shock at follow-up. We also provide robust evidence indicating that the quantification of the BrS arrhythmic risk score at the moment of ICD implant may improve the identification of patients who will benefit from ICD at follow-up.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular Medicine, University of Pavia, Via Adolfo Ferrata, Pavia 27100, Italy.",
    "Molecular Cardiology Unit Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, Pavia 27100, Italy.",
    "Cardiothoracic Department IRCCS Galeazzi-Sant' Ambrogio, Arrhythmia and Electrophysiology Unit, Milan, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Carlo Napolitano",
      "orcid": "0000-0002-7643-4628"
    },
    {
      "affs": [
        1
      ],
      "name": "Camilla Pizzetti",
      "orcid": "0009-0000-5161-2937"
    },
    {
      "affs": [
        1
      ],
      "name": "Deni Kukavica",
      "orcid": "0000-0002-7152-5934"
    },
    {
      "affs": [
        1
      ],
      "name": "Massimo Morini",
      "orcid": "0000-0002-7054-9109"
    },
    {
      "affs": [
        2
      ],
      "name": "Luca Ottaviano",
      "orcid": "0000-0003-1496-8963"
    },
    {
      "affs": [
        0
      ],
      "name": "Umberto Giordano"
    },
    {
      "affs": [
        1
      ],
      "name": "Mirella Memmi",
      "orcid": "0000-0003-4006-5661"
    },
    {
      "affs": [
        1
      ],
      "name": "Patrick Gambelli",
      "orcid": "0000-0002-0040-3411"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Andrea Mazzanti",
      "orcid": "0000-0002-0208-2172"
    },
    {
      "affs": [
        1
      ],
      "name": "Lucia Coppini"
    },
    {
      "affs": [
        1
      ],
      "name": "Alessandro Trancuccio",
      "orcid": "0000-0002-2181-8245"
    },
    {
      "affs": [
        1
      ],
      "name": "Gianluca Pili",
      "orcid": "0000-0002-3748-3734"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Silvia G Priori",
      "orcid": "0000-0001-6877-0288"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ce33vj7cty19f.bib",
  "cited_by": 0,
  "doi": "10.1093/europace/euag278",
  "fulltext_url": "https://europepmc.org/articles/PMC13685634",
  "id": "ce33vj7cty19f",
  "issns": [
    "1099-5129",
    "1532-2092"
  ],
  "landing_url": "https://europepmc.org/article/MED/42905523",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiac electrophysiology and arrhythmias"
    ]
  ],
  "openalex": "W7223103836",
  "pdf_url": "https://europepmc.org/articles/PMC13685634?pdf=render",
  "pmcid": "PMC13685634",
  "pmid": "42905523",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ce33vj7cty19f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42905523",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905523"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac electrophysiology and arrhythmias",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Long-term predictors of outcome in Brugada syndrome patients after implantable cardioverter-defibrillator implant.",
  "title_text": "Long-term predictors of outcome in Brugada syndrome patients after implantable cardioverter-defibrillator implant.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/ce33vj7cty19f",
  "venue": "Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology",
  "versions": []
}