{
  "abstract": "Background: Acute myeloid leukemia (AML) predominantly affects older adults; however, patients 75 years of age and older are often not candidates for curative-intent treatments. Data on their treatment patterns, survival outcomes, and healthcare utilization are limited, and we evaluated these outcomes among patients 75 years of age and older with AML. Methods: We retrospectively analyzed 97 patients aged 75 years and older managed at our academic safety-net hospital between 2016 and 2025. Results: Median overall survival (mOS) was 95 days for all patients. Receipt of any AML-directed therapy was associated with longer mOS compared with no leukemia-directed treatment (144 days, 95% CI: 98–184 vs. 17 days, 95% CI: 7–50; p < 0.001). Among patients with 2024 ELN adverse-risk/TP53-mutated disease, mOS was 88 days (95% CI: 34-NE) with AML-directed therapy and 44 days (CI: 36-NE) without treatment (p = 0.2). Forty-four percent of patients were enrolled in a hospice at their time of death, and an additional 40% were managed with comfort measures as inpatients. Median duration of hospice or comfort care was 2 days (IQR: 1–5), with no difference based on whether patients received any AML-directed treatment. Fifty-one percent of patients died in the hospital. Conclusions: Our findings highlight real-world challenges for older adults with AML, including the need for more effective treatments for patients with TP53-mutated AML. AML-directed treatment was associated with longer survival without a decrease in the time spent in hospice care, and the risk of in-hospital mortality remains elevated for this population.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Hematology/Oncology, Department of Medicine, UMass Memorial Medical Center, UMass Chan Medical School, Worcester, MA 01655, USA",
    "Department of Medicine, UMass Memorial Medical Center, UMass Chan Medical School, Worcester, MA 01655, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tina Y. Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Alex Y. Ge"
    },
    {
      "affs": [
        0
      ],
      "name": "Shyam A. Patel",
      "orcid": "0000-0002-8208-1902"
    },
    {
      "affs": [
        0
      ],
      "name": "Poorva Bindal"
    },
    {
      "affs": [
        0
      ],
      "name": "Jan Cerny",
      "orcid": "0000-0002-6602-5505"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrew Gillis-Smith"
    },
    {
      "affs": [
        0
      ],
      "name": "Muthalagu Ramanathan"
    },
    {
      "affs": [
        0
      ],
      "name": "Sakiko Suzuki",
      "orcid": "0009-0005-5452-6096"
    },
    {
      "affs": [
        0
      ],
      "name": "Laurie Pearson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cexh54vtet9k9.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18193230",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664294/?tool=EBI",
  "id": "cexh54vtet9k9",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13664294",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7220929780",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664294/pdf/?tool=EBI",
  "pmcid": "PMC13664294",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/cexh54vtet9k9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "PMC:PMC13664294",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13664294"
    },
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18193230",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/19/3230"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6694",
      "subfield": "oncology"
    }
  ],
  "title": "Contemporary Clinical Outcomes and Healthcare Utilization in Older Adults with Acute Myeloid Leukemia: Insights from a Single-Center Retrospective Cohort",
  "title_text": "Contemporary Clinical Outcomes and Healthcare Utilization in Older Adults with Acute Myeloid Leukemia: Insights from a Single-Center Retrospective Cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:58Z",
  "url": "https://research.draconitic.com/paper/cexh54vtet9k9",
  "venue": "Cancers",
  "versions": []
}