{
  "abstract": "The central problem when delivering drugs to the brain is no longer crossing the blood–brain barrier, but delivering therapeutics to the right cells, in the right regions to target neurodegeneration, within a dynamically changing neurovascular unit.\n\nCrossing the blood–brain barrier is no longer a problem for delivering therapeutics to the brain. This Perspective argues that the main challenge is now how to deliver therapeutics to the right cells, in the right regions to target neurodegeneration, within a dynamically changing neurovascular unit.",
  "abstract_shown": true,
  "affiliations": [
    "School of Life Sciences, Reutlingen University, Reutlingen, Germany"
  ],
  "article_type": "Perspective",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lavanya Gupta"
    },
    {
      "name": "Sinem Agilkaya"
    },
    {
      "name": "Kim Susann Keller"
    },
    {
      "name": "Ebru Ercan-Herbst"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cexwhccbq309q.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pbio.3004049",
  "fulltext_url": "https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004049",
  "id": "cexwhccbq309q",
  "issns": [
    "1545-7885",
    "1544-9173"
  ],
  "landing_url": "https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004049",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Nervous system/Central nervous system"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Nervous system/Central nervous system/Blood-brain barrier"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular structures and organelles/Lysosomes"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cytosol"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Nervous system/Central nervous system"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Nervous system/Central nervous system/Blood-brain barrier"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Brain diseases"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Neurodegenerative diseases"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Neurodegenerative diseases/Motor neuron diseases"
    ],
    [
      "plos",
      "/Medicine and health sciences/Neurology/Brain diseases"
    ],
    [
      "plos",
      "/Medicine and health sciences/Neurology/Neurodegenerative diseases"
    ],
    [
      "plos",
      "/Medicine and health sciences/Neurology/Neurodegenerative diseases/Motor neuron diseases"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmaceutics/Drug delivery"
    ]
  ],
  "openalex": "W7223688513",
  "pdf_url": "https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3004049&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/cexwhccbq309q.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.1371/journal.pbio.3004049",
      "source": "plos",
      "url": "https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004049"
    },
    {
      "first_seen": "2026-10-31T14:22:28Z",
      "native_id": "13aa17a9100e44b0977c66d2a69c286e",
      "source": "doaj",
      "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13704838/?tool=EBI"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:cell biology",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "plos:neurology",
      "subfield": "neurology"
    },
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Therapeutic delivery systems need to focus on cellular precision to target neurodegeneration",
  "title_text": "Therapeutic delivery systems need to focus on cellular precision to target neurodegeneration",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:28Z",
  "url": "https://research.draconitic.com/paper/cexwhccbq309q",
  "venue": "PLOS Biology",
  "versions": []
}