{
  "abstract": "Purpose: The international REQUITE study and its follow-up studies (RADprecise/REQUITEplus) prospectively collected longitudinal data from patients undergoing radiotherapy for breast, prostate, or lung cancer. We present data from 2057 women with breast cancer, describing patient-reported outcomes and acute and late adverse effects.\n\nMethods: Patients were recruited between April 2014 and October 2016. Eligible patients received external-beam photon radiotherapy after breast-conserving surgery, had no metastasis at inclusion, no other malignancy within the previous five years, and no prior breast irradiation. Blood samples were collected before radiotherapy for genotyping, molecular analysis, and biobanking. Standardised assessments included CTCAE v4, EORTC QLQ-C30 and BR23, MFI, GPAQ, and DICOM/DVH data. Follow-up continued annually for two years, extending to eight years at eligible sites.\n\nResults: Acute side effects peaked at end of radiotherapy, with erythema in 83–89% of patients. Grade ≥ 2 acute effects, including pain (11% versus 4.3%) and skin ulceration (4.8% versus 0.8%), were more frequent with normofractionation than hypofractionation. Grade ≥ 2 late effects affected between 0.6% and 16.8% of patients; skin induration was the most frequent late effect. Patient-reported outcome scores varied over time, with functional scale scores at two years similar to or higher than at baseline.\n\nConclusion: REQUITE provides real-world evidence of acute and late outcomes following normo- and hypofractionation, broadly consistent with published randomised trials. The dataset, combining clinical adverse effects, quality of life, dosimetric, and genetic data, is a resource for personalised radiotherapy research (www.requite.eu).",
  "abstract_shown": true,
  "affiliations": [
    "Mannheim Comprehensive Cancer Center, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany",
    "Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany",
    "University of Leicester, United Kingdom",
    "Grupo Genética en Cáncer y Enfermedades Raras, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain",
    "Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain",
    "Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain",
    "Programa de Doctorat en Biomedicina, Universitat de Barcelona (UB), Barcelona, Spain",
    "Department of Radiation Oncology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain",
    "University of Manchester, Christie Hospital NHS Foundation Trust, United Kingdom",
    "Fédération Universitaire d'Oncologie Radiothérapie d'Occitanie Méditerranée, ICM, Univ Montpellier INSERM U1194 IRCM, Montpellier, France",
    "Patient Advocate, United Kingdom",
    "Department of Human Structure and Repair, Ghent University, Ghent, Belgium",
    "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany",
    "Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy",
    "University of Cambridge, United Kingdom",
    "Wellcome Sanger Institute, United Kingdom",
    "Medical Faculty Heidelberg, Heidelberg University, Germany",
    "Leicester Cancer Research Centre, University of Leicester, Leicester, UK",
    "Medical College of Wisconsin, USA",
    "UZ Leuven, Belgium",
    "Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy",
    "Radiation Oncology Department, Hospital Clinic of Barcelona, Spain",
    "Departments of Radiation Oncology & Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA",
    "MAASTRO Clinic, Maastricht, Netherlands",
    "Division of Personalized Early Detection of Prostate Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany",
    "The Christie NHS Foundation Trust, United Kingdom",
    "Department of Radiation Oncology, Hospital Clínico Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Spain",
    "Ghent University Hospital, Belgium"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 45,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Tina Bockstiegel"
    },
    {
      "affs": [
        2
      ],
      "name": "Adam Webb"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Miguel E. Aguado-Barrera"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Ester Aguado-Flor"
    },
    {
      "affs": [
        7
      ],
      "name": "Manuel Altabas"
    },
    {
      "affs": [
        8
      ],
      "name": "Marianne Aznar"
    },
    {
      "affs": [
        9
      ],
      "name": "David Azria"
    },
    {
      "affs": [
        10
      ],
      "name": "Erik Briers"
    },
    {
      "affs": [
        11
      ],
      "name": "Renée Bultijnck"
    },
    {
      "affs": [
        12
      ],
      "name": "Jenny Chang-Claude"
    },
    {
      "affs": [
        13
      ],
      "name": "Alessandro Cicchetti"
    },
    {
      "affs": [
        13
      ],
      "name": "Maria Carmen De Santis"
    },
    {
      "affs": [
        14
      ],
      "name": "Alison Dunning"
    },
    {
      "affs": [
        15
      ],
      "name": "Laura Fachal"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Olivia Fuentes-Rios"
    },
    {
      "affs": [
        7
      ],
      "name": "Alexandra Giraldo"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Antonio Gómez-Caamaño"
    },
    {
      "affs": [
        5
      ],
      "name": "Sara Gutiérrez-Enríquez"
    },
    {
      "affs": [
        1
      ],
      "name": "Carsten Herskind"
    },
    {
      "affs": [
        12,
        16
      ],
      "name": "Philipp Heumann"
    },
    {
      "affs": [
        17
      ],
      "name": "Kerstie Johnson"
    },
    {
      "affs": [
        12
      ],
      "name": "Rudolf Kaaks"
    },
    {
      "affs": [
        18
      ],
      "name": "Sarah L. Kerns"
    },
    {
      "affs": [
        19
      ],
      "name": "Maarten Lambrecht"
    },
    {
      "affs": [
        20
      ],
      "name": "Eliana La Rocca"
    },
    {
      "affs": [
        7,
        21
      ],
      "name": "Meritxell Mollà"
    },
    {
      "affs": [
        13
      ],
      "name": "Tiziana Rancati"
    },
    {
      "affs": [
        7
      ],
      "name": "Victoria M. Reyes"
    },
    {
      "affs": [
        12
      ],
      "name": "Juan Camilo Rosas Romero"
    },
    {
      "affs": [
        22
      ],
      "name": "Barry S. Rosenstein"
    },
    {
      "affs": [
        23
      ],
      "name": "Dirk De Ruysscher"
    },
    {
      "affs": [
        12,
        24
      ],
      "name": "Petra Seibold"
    },
    {
      "affs": [
        25
      ],
      "name": "Rebecca M. Shearer"
    },
    {
      "affs": [
        10
      ],
      "name": "Hilary Stobart"
    },
    {
      "affs": [
        10
      ],
      "name": "R. Paul Symonds"
    },
    {
      "affs": [
        3,
        26
      ],
      "name": "Begoña Taboada-Valladares"
    },
    {
      "affs": [
        2
      ],
      "name": "Christopher J. Talbot"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Ana Vega"
    },
    {
      "affs": [
        27
      ],
      "name": "Liv Veldeman"
    },
    {
      "affs": [
        1
      ],
      "name": "Marlon R. Veldwijk"
    },
    {
      "affs": [
        10
      ],
      "name": "Tim Ward"
    },
    {
      "affs": [
        8
      ],
      "name": "Catharine M.L. West"
    },
    {
      "name": "REQUITE/REQUITEplus/RADprecise consortia"
    },
    {
      "affs": [
        2
      ],
      "name": "Tim Rattay"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elena Sperk"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cezps7ff192v9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ctro.2026.101307",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696215/",
  "id": "cezps7ff192v9",
  "issns": [
    "2405-6308"
  ],
  "landing_url": "https://doi.org/10.1016/j.ctro.2026.101307",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "openalex",
      "1306|Breast Cancer Treatment Studies"
    ]
  ],
  "openalex": "W7220966352",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13696215/pdf/?tool=EBI",
  "pmcid": "PMC13696215",
  "pmid": "42935767",
  "published": "2026-10-07",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/cezps7ff192v9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "PMC13696215",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ctro.2026.101307"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13696215",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13696215"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Breast Cancer Treatment Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Early and late CTCAE and patient-reported outcomes following breast radiotherapy in the REQUITE cohort",
  "title_text": "Early and late CTCAE and patient-reported outcomes following breast radiotherapy in the REQUITE cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:35Z",
  "url": "https://research.draconitic.com/paper/cezps7ff192v9",
  "venue": "Clinical and Translational Radiation Oncology",
  "versions": []
}