{
  "abstract": "Parkinson's disease is defined by dopaminergic neuron loss in the substantia nigra, yet its hallmark, exaggerated beta-band synchrony, pervades motor cortex, thalamus, and cerebellum, implicating network dynamics far beyond any single circuit. How focal subcortical dopamine depletion translates into brain-wide oscillatory pathology remains unresolved. We use a connectome-constrained multiscale model of the mouse brain, embedding biophysically detailed spiking networks of basal ganglia and cerebellum within whole-brain corticothalamic dynamics grounded in the Allen Mouse Brain Connectivity Atlas. We show that confining dopamine depletion exclusively to subcortical circuits is sufficient to produce widespread beta hypersynchrony (10-30 Hz), accompanied by heterogeneous theta and gamma dysregulation. Virtual loop ablations reveal that cortical and cerebellar beta amplification strictly requires intact cortico-basal ganglia-thalamic feedback; severing this loop confines beta to subcortical generators. These results support resonance within closed large-scale loops, rather than local rhythmogenesis, as the mechanism underlying distributed Parkinsonian beta pathology.",
  "abstract_shown": true,
  "affiliations": [
    "Politecnico di Milano"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "B. Gambosi"
    },
    {
      "name": "D. Perdikis"
    },
    {
      "name": "J. Meier"
    },
    {
      "name": "A. Geminiani"
    },
    {
      "name": "A. Antonietti"
    },
    {
      "name": "A. Mazzoni"
    },
    {
      "name": "G. Ferrigno"
    },
    {
      "name": "P. Ritter"
    },
    {
      "name": "A. Pedrocchi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cf7ksd32x1x16.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.05.15.725133",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.05.15.725133v2.full",
  "id": "cf7ksd32x1x16",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.05.15.725133v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2805|Neural dynamics and brain function"
    ]
  ],
  "openalex": "W7161556896",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.05.15.725133v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cf7ksd32x1x16.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.64898/2026.05.15.725133",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.05.15.725133v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Dopamine Depletion Drives Whole-Brain Oscillatory Disruptions via Cortico-Subcortical Resonance: A Multiscale Model of Parkinson's Disease in Mice",
  "title_text": "Dopamine Depletion Drives Whole-Brain Oscillatory Disruptions via Cortico-Subcortical Resonance: A Multiscale Model of Parkinson's Disease in Mice",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/cf7ksd32x1x16",
  "venue": "bioRxiv",
  "versions": []
}