{
  "abstract": "Purpose\n\nPrurigo nodularis (PN) is chronic pruritic dermatosis with hyperkeratotic nodules and persistent itch, occurring alone or with atopic dermatitis (AD). The molecular basis of nodular architecture and sustained pruritus remain poorly defined, particularly the role of fibroblasts and their interactions with neuronal components. This study aimed to identify PN-specific pathogenic profiles by comparing lesional transcriptomes from AD, atopic prurigo (AP), and PN.Methods\n\nBulk RNA sequencing was performed on lesional skin from AD (n = 6), AP (n = 7), PN (n = 7), and healthy controls (HC; n = 4). Publicly available single-cell RNA-sequencing datasets were reanalyzed for cell-type signatures. Integrated analyses included differentially expressed genes, pathway enrichment, cell-type deconvolution, ligand-receptor inference, and immune cell profiling.Results\n\nPN lesions showed MAPK/ERK pathway enrichment in fibroblasts compared with AD and AP. NRXN1+ cells were inferred as major interacting partners of fibroblasts, with ligand-receptor interactions consistent with enhanced fibroblast MAPK/ERK activity. Immune pathway analyses showed weaker Th2 pathway activity in PN compared with AD/AP, providing context for neuronal-stromal interactions as a putative distinguishing feature.Conclusions\n\nPN shows enhanced MAPK/ERK pathway enrichment in fibroblasts and inferred NRXN1+ cell-fibroblast interactions. This candidate axis may contribute to nodular lesion architecture and persistent pruritus, suggesting potential therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea.",
    "Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea.",
    "Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.",
    "Department of Dermatology, National Medical Center, Seoul, Korea.",
    "Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea. jongil@snu.ac.kr.",
    "Department of Dermatology, National Medical Center, Seoul, Korea. jiyoung.ahn@nmc.or.kr."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiyun Jang",
      "orcid": "0000-0001-5145-334X"
    },
    {
      "affs": [
        2
      ],
      "name": "Young-Bok Lee",
      "orcid": "0000-0002-8642-2479"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hwee-Seon Park",
      "orcid": "0000-0002-2649-3750"
    },
    {
      "affs": [
        3
      ],
      "name": "Narang Hong",
      "orcid": "0000-0002-6542-4811"
    },
    {
      "affs": [
        3
      ],
      "name": "Hyung Don Kook",
      "orcid": "0000-0001-6687-2125"
    },
    {
      "affs": [
        3
      ],
      "name": "Hye Jung Jung",
      "orcid": "0000-0003-0995-5711"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Jong-Il Kim",
      "orcid": "0000-0002-7240-3744"
    },
    {
      "affs": [
        5
      ],
      "name": "Jiyoung Ahn",
      "orcid": "0000-0002-6766-9978"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cfem5rde4w7zv.bib",
  "cited_by": 0,
  "doi": "10.4168/aair.2026.18.5.761",
  "fulltext_url": "https://europepmc.org/articles/PMC13655402",
  "id": "cfem5rde4w7zv",
  "issns": [
    "2092-7355",
    "2092-7363"
  ],
  "landing_url": "https://europepmc.org/article/MED/42845230",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Dermatology and Skin Diseases"
    ]
  ],
  "openalex": "W7214741621",
  "pdf_url": "https://europepmc.org/articles/PMC13655402?pdf=render",
  "pmcid": "PMC13655402",
  "pmid": "42845230",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cfem5rde4w7zv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42845230",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42845230"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Dermatology and Skin Diseases",
      "subfield": "general"
    }
  ],
  "title": "Integrated RNA-Seq Profiling Identifies NRXN1+ Cell-Fibroblast Associated MAPK Signaling in Prurigo Nodularis.",
  "title_text": "Integrated RNA-Seq Profiling Identifies NRXN1+ Cell-Fibroblast Associated MAPK Signaling in Prurigo Nodularis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/cfem5rde4w7zv",
  "venue": "Allergy, asthma & immunology research",
  "versions": []
}