{
  "abstract": "The circulating metabolome is a vital intermediate layer linking genetics to complex phenotypes, yet existing genome-wide studies-even in humans-rarely capture dynamic physiological contexts or cellular regulatory mechanisms. Here, we present the Cattle Metabolome Atlas (https://cattlema.farmgtex.org/), a comprehensive resource of 3,436 plasma metabolites and 4,851 serum metabolites from 4,651 animals with matched sequence-level genotypes across highly dynamic parity and lactation stages. We mapped 728 plasma and 622 serum metabolite quantitative trait loci (mQTL), revealing widespread context-dependent regulatory architectures. Integrating these mQTL with the multi-tissue expression quantitative trait loci (eQTL) and single-cell atlas of 59 tissues demonstrates that 74-79% of mQTL colocalize with eQTL across 29 tissues, prioritizing the liver as the primary systemic hub and resolving metabolic programs at single-cell resolution. Furthermore, we charted 538 causal gene-tissue-metabolite-trait cascades across 11 complex traits in cattle. Finally, cross-species analyses demonstrate partial evolutionary conservation of genetic metabolism between cattle and humans, establishing this atlas as a powerful asset for cattle genetics and genomics, selective breeding, and comparative biology.",
  "abstract_shown": true,
  "affiliations": [
    "Shandong Academy of Agricultural Sciences"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "name": "J. Teng"
    },
    {
      "name": "H. Li"
    },
    {
      "name": "J. Yang"
    },
    {
      "name": "J. Lu"
    },
    {
      "name": "C. Duan"
    },
    {
      "name": "Z. Chen"
    },
    {
      "name": "X. Zhang"
    },
    {
      "name": "X. Zhao"
    },
    {
      "name": "F. Pei"
    },
    {
      "name": "X. Wu"
    },
    {
      "name": "P. Zhao"
    },
    {
      "name": "H. Zhang"
    },
    {
      "name": "H. Gao"
    },
    {
      "name": "L. Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "D. Wang"
    },
    {
      "name": "C. Ning"
    },
    {
      "name": "H. Liu"
    },
    {
      "name": "G. Su"
    },
    {
      "name": "R. Li"
    },
    {
      "name": "Y. Gao"
    },
    {
      "name": "J. Li"
    },
    {
      "name": "Q. Zhang"
    },
    {
      "name": "L. Fang"
    },
    {
      "affs": [
        0
      ],
      "name": "X. Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cfm9q4rw37sbf.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.05.749592",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.05.749592v1.full",
  "id": "cfm9q4rw37sbf",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.05.749592v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "genetics"
    ],
    [
      "openalex",
      "1311|Genetic and phenotypic traits in livestock"
    ]
  ],
  "openalex": "W7212386230",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.05.749592v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cfm9q4rw37sbf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:36Z",
      "native_id": "10.64898/2026.09.05.749592",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.05.749592v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:genetics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Genetic regulation of circulating metabolome in cattle",
  "title_text": "Genetic regulation of circulating metabolome in cattle",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:36Z",
  "url": "https://research.draconitic.com/paper/cfm9q4rw37sbf",
  "venue": "bioRxiv",
  "versions": []
}