{
  "abstract": "Late-onset preeclampsia (LOPE) is a major pregnancy complication characterized by hypertension and placental dysfunction, resolving only upon delivery. Here, we show that LOPE placentae undergo accelerated molecular aging, marked by telomere attrition, DNA damage, and trophoblast senescence. Using primary placental tissue and trophoblast organoids, we demonstrate oxidative stress as a driver of telomere shortening and angiogenic imbalance. Inflammation did not alter placental aging trajectories. Antioxidant treatment (superoxide dismutase) preserved telomere length, reduced DNA damage, and restored angiogenic balance, highlighting oxidative stress as a modifiable determinant of placental aging. We identify reduced expression of telomeric repeat-containing RNAs (TERRAs) as a molecular hallmark of LOPE, and show that antisense oligonucleotide-mediated TERRA depletion exacerbates telomere erosion and senescence. Together, these findings delineate oxidative stress and TERRA loss as mechanisms driving placental decline, establish trophoblast organoids as a tractable model of placental aging, and reveal potential therapeutic avenues for mitigating preeclampsia-associated placental dysfunction.",
  "abstract_shown": true,
  "affiliations": [
    "Discipline of Women's and Children's Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5042, Australia.",
    "College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.",
    "Robinson Research Institute, University of Adelaide, Adelaide, SA 5000, Australia.",
    "Adelaide Centre for Epigenetics, School of Biomedicine, and South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA 5000, Australia.",
    "Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Parkville, VIC 3010, Australia.",
    "Gynaecology Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia.",
    "Department of Obstetrics and Gynaecology, University of Nebraska Medical Center, Omaha, NE 68198."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Anya L Arthurs",
      "orcid": "0000-0002-4382-0610"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Rudrarup Bhattacharjee",
      "orcid": "0000-0003-2740-6986"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Melanie D Smith"
    },
    {
      "affs": [
        3
      ],
      "name": "Dulce L Medina Garcia"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Ellen Menkhorst",
      "orcid": "0000-0003-2440-6665"
    },
    {
      "affs": [
        3
      ],
      "name": "German Mora"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jessica M Williamson",
      "orcid": "0000-0002-6332-7874"
    },
    {
      "affs": [
        6
      ],
      "name": "Lynda K Harris"
    },
    {
      "affs": [
        3
      ],
      "name": "Jose M Polo"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "David A MacIntyre",
      "orcid": "0000-0002-4186-5567"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Claire T Roberts",
      "orcid": "0000-0002-9250-2192"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cg1q34r3a192h.bib",
  "cited_by": 0,
  "doi": "10.1073/pnas.2614827123",
  "fulltext_url": "https://europepmc.org/articles/PMC13663791",
  "id": "cg1q34r3a192h",
  "issns": [
    "0027-8424",
    "1091-6490"
  ],
  "landing_url": "https://europepmc.org/article/MED/42837445",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Pregnancy and preeclampsia studies"
    ]
  ],
  "openalex": "W7220725066",
  "pdf_url": "https://europepmc.org/articles/PMC13663791?pdf=render",
  "pmcid": "PMC13663791",
  "pmid": "42837445",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cg1q34r3a192h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42837445",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42837445"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Pregnancy and preeclampsia studies",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Late-onset preeclampsia is characterized by accelerated placental aging.",
  "title_text": "Late-onset preeclampsia is characterized by accelerated placental aging.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/cg1q34r3a192h",
  "venue": "Proceedings of the National Academy of Sciences of the United States of America",
  "versions": []
}