{
  "abstract": "retinal chromophore leading to a metastable twisted diradical (TIDIR), in clear contrast to the standard charge-transfer scenario established for other microbial rhodopsins. We discuss how the presence of TIDIR makes AR-3 an ideal candidate for the design of variants with a one-photon induced fluorescence possibly reaching the emission quantum yield of the top natural emitter neorhodopsin (NeoR).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Krystyna Herasymenko"
    },
    {
      "name": "Danushka Walisinghe"
    },
    {
      "name": "Masae Konno"
    },
    {
      "name": "Leonardo Barneschi"
    },
    {
      "name": "Isabelle de Waele"
    },
    {
      "name": "Michel Sliwa"
    },
    {
      "name": "Keiichi Inoue"
    },
    {
      "name": "Massimo Olivucci"
    },
    {
      "name": "Stefan Haacke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cgbngaw8f0f7m.bib",
  "cited_by": 9,
  "doi": "10.1039/d4sc05120c",
  "fulltext_url": null,
  "id": "cgbngaw8f0f7m",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://hal.science/hal-05780454v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "0.phys"
    ],
    [
      "openalex",
      "2804|Photoreceptor and optogenetics research"
    ]
  ],
  "openalex": "W4404462806",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "The Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/cgbngaw8f0f7m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:48Z",
      "native_id": "hal-05780454",
      "source": "hal",
      "url": "https://hal.science/hal-05780454v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Photoreceptor and optogenetics research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Archaerhodopsin 3 is an ideal template for the engineering of highly fluorescent optogenetic reporters",
  "title_text": "Archaerhodopsin 3 is an ideal template for the engineering of highly fluorescent optogenetic reporters",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:48Z",
  "url": "https://research.draconitic.com/paper/cgbngaw8f0f7m",
  "venue": "Chemical Science",
  "versions": []
}