{
  "abstract": "Objective\n\nThis study aimed to investigate the association between baseline neutrophil-lymphocyte ratio (NLR), mean corpuscular volume (MCV), and Catheter-Related Bloodstream Infection (CRBSI).Methods\n\nA retrospective case-control design was employed. The study included 27 patients diagnosed with CRBSI at the first affiliated hospital of fujian medical university, between January 2022 to December 2023, who were matched in a 1:2 ratio with 54 non-infected controls. Data were analyzed using multivariate logistic regression, receiver operating characteristic (ROC) curve analysis, and multifactor dimensionality reduction (MDR).Results\n\nNLR was identified as an independent risk factor for CRBSI (OR = 1.088, P = 0.028), while MCV served as a protective factor (OR = 0.911, P = 0.016). ROC analysis showed that MCV had an AUC of 0.706 and NLR had an AUC of 0.635, with no statistically significant difference between the two AUCs. MDR analysis further revealed a significant interaction between MCV and NLR (P < 0.001). The high-risk combination (MCV < 91.5 fL and NLR ≥ 8.3) was associated with an increased odds of CRBSI (OR = 36). The prediction model constructed based on this interaction combination achieved an accuracy of 76.7%, with a 10/10 consistency in tenfold cross-validation.Conclusion\n\nThe interaction between elevated pre-catheterization NLR and decreased MCV may serve as complementary indicators for CRBSI risk assessment, facilitating early identification of high-risk patients and guiding the implementation of targeted preventive strategies in clinical practice.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.",
    "Radiation Oncology Center, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fuzhou, 350212, China.",
    "Department of Clinical Research and Translation Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.",
    "Nursing Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China. qiaoxianzhang@163.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiurong Song"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Junjun Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lingxia Shi"
    },
    {
      "affs": [
        2
      ],
      "name": "Shuna Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Ke Ma"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Fan Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Liyun Lin"
    },
    {
      "affs": [
        3
      ],
      "name": "Qiaoxian Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cgkpfp05z499x.bib",
  "cited_by": 0,
  "doi": "10.1186/s12879-026-14225-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13749669",
  "id": "cgkpfp05z499x",
  "issns": [
    "1471-2334"
  ],
  "landing_url": "https://europepmc.org/article/MED/43009818",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7202242366",
  "pdf_url": "https://europepmc.org/articles/PMC13749669?pdf=render",
  "pmcid": "PMC13749669",
  "pmid": "43009818",
  "published": "2026-08-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cgkpfp05z499x.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43009818",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43009818"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Baseline neutrophil-to-lymphocyte ratio and mean corpuscular volume and their association with catheter-related bloodstream infection: a retrospective case-control study.",
  "title_text": "Baseline neutrophil-to-lymphocyte ratio and mean corpuscular volume and their association with catheter-related bloodstream infection: a retrospective case-control study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:20:45Z",
  "url": "https://research.draconitic.com/paper/cgkpfp05z499x",
  "venue": "BMC infectious diseases",
  "versions": []
}