{
  "abstract": "Small-sized gold nanoparticles (AuNPs) functionalised with hydrophilic thiols were investigated. Sodium 3-mercapto-1-sulfonate and 2-(diethylamino)ethanethiol hydrochloride were used as stabilising agents in a wet synthesis approach to provide a stable colloidal system. AuNPs were loaded with the antibody trastuzumab (TZ) to evaluate the potential use of the system for photothermal-assisted controlled drug release. Furthermore, to gain a deeper understanding of the chemical interactions occurring at the interface between TZ and the surface thiols of the nanoparticles, FT-IR studies were performed both in the solid state and in suspension, suggesting a strong interaction between the surface thiols and the amidic functional groups of TZ. The photothermal (PT) behaviour of the pristine AuNPs was investigated under continuous-wave laser irradiation at 532 nm, matching the plasmon resonance band of the gold nanoparticles, resulting in an up to 20 °C temperature increase. FT-IR measurements were also carried out after laser irradiation to evaluate the potential for a controlled release of TZ from the nanoparticle surface, suggesting that light irradiation can trigger the release of the drug from the AuNPs surface, with no detrimental effect from the temperature increase. Finally, SAXS studies enabled the investigation of TZ loading and release kinetics via in situ studies over 3 hours. This work provided a detailed investigation of the interfacial chemical interactions, also giving a dual potential application of the hybrid, evaluating its use for PT therapy and for PT-assisted controlled release of the antibody.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical and Molecular Medicine, Sapienza University of Rome Rome 00189 Italy",
    "Department of Chemistry, Sapienza University of Rome Rome 00185 Italy",
    "Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome 00161 Rome Italy",
    "Department of Physics, Sapienza University of Rome Rome 00185 Italy",
    "National Research Council, Department of Chemical Sciences and Materials Technologies, Institute of Crystallography Montelibretti 00010 Italy",
    "Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Latina 04100 Italy",
    "Institute of Physics, University of Siegen Siegen D-57068 Germany",
    "Fakultät Physik/DELTA, Technische Universität Dortmund 44221 Dortmund Germany",
    "Department of Experimental Medicine, Sapienza University of Rome Rome 00161 Italy"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Tommaso A. Salamone"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Rosanna Mosetti"
    },
    {
      "affs": [
        3
      ],
      "name": "Annalisa D'Arco"
    },
    {
      "affs": [
        3
      ],
      "name": "Stefano Lupi"
    },
    {
      "affs": [
        4
      ],
      "name": "Francesca Petronella"
    },
    {
      "affs": [
        5
      ],
      "name": "Arianna Avitabile"
    },
    {
      "affs": [
        5
      ],
      "name": "Flaminia Pompeo"
    },
    {
      "affs": [
        5
      ],
      "name": "Luciano De Sio",
      "orcid": "0000-0002-2183-6910"
    },
    {
      "affs": [
        0
      ],
      "name": "Sofia Marotta"
    },
    {
      "affs": [
        0
      ],
      "name": "Stella Mrmić"
    },
    {
      "affs": [
        1
      ],
      "name": "Beatrice Pennacchi"
    },
    {
      "affs": [
        1
      ],
      "name": "Sara Cerra",
      "orcid": "0000-0002-5549-9406"
    },
    {
      "affs": [
        6
      ],
      "name": "Souren Grigorian"
    },
    {
      "affs": [
        7
      ],
      "name": "Michael Paulus"
    },
    {
      "affs": [
        0
      ],
      "name": "Maurizio Alimandi"
    },
    {
      "affs": [
        8
      ],
      "name": "Pankaj Trivedi"
    },
    {
      "affs": [
        0
      ],
      "name": "Eleni Anastasiadou"
    },
    {
      "affs": [
        1
      ],
      "name": "Ilaria Fratoddi",
      "orcid": "0000-0002-5172-0636"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cgnxemmsxxxkc.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra07147c",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667367/?tool=EBI",
  "id": "cgnxemmsxxxkc",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13667367",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2504|Gold and Silver Nanoparticles Synthesis and Applications"
    ]
  ],
  "openalex": "W7221808012",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667367/pdf/?tool=EBI",
  "pmcid": "PMC13667367",
  "pmid": "42877328",
  "published": "2026-10-14",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/cgnxemmsxxxkc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "PMC:PMC13667367",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13667367"
    },
    {
      "first_seen": "2026-11-01T12:23:38Z",
      "native_id": "PMC13667367",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra07147c"
    }
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2504|Gold and Silver Nanoparticles Synthesis and Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Mixed-thiol functionalised gold nanoparticles for trastuzumab delivery: chemical interaction and photothermal therapeutic potential",
  "title_text": "Mixed-thiol functionalised gold nanoparticles for trastuzumab delivery: chemical interaction and photothermal therapeutic potential",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:52Z",
  "url": "https://research.draconitic.com/paper/cgnxemmsxxxkc",
  "venue": "RSC advances",
  "versions": []
}