{
  "abstract": "Objectives\n\nDouble-lung transplantation (DLTx) has become the treatment of choice for patients with end-stage pulmonary hypertension (PH). However, DLTx remains a demanding procedure, associated with a greater incidence of severe primary graft dysfunction (PGD) compared with other indications. PH-induced cardiac remodeling includes diastolic left heart dysfunction, which may increase the risk of PGD. We hypothesized that continuous monitoring of left atrial pressure (LAP) could improve early outcomes.Methods\n\nWe retrospectively reviewed the chart of patients who underwent DLTx for PH between 2015 and 2022. The use of postoperative LAP monitoring was left to the discretion of the attending transplant surgeon.Results\n\nA total of 135 patients underwent DLTx for PH. Among them, 72 were managed either with prophylactic postoperative extracorporeal membrane oxygenation (ECMO) or with ECMO weaning guided by transesophageal echocardiography and Swan-Ganz catheter, whereas 63 underwent systematic ECMO weaning after the placement of a LAP catheter maintained for 3 to 5 days. Both groups were comparable regarding age, PH diagnoses, and disease severity. The LAP group showed significantly less postoperative ECMO use (25% vs 83%, P < .001), shorter duration of mechanical ventilation (5 days [2-13] vs 17.5 days [7-35], P < .001), shorter stay in the intensive care unit (10 days [6-25] vs 28 days [14-49], P < .001), and lower rates of bleeding, groin infection, and overall complications (P ≤ .05). Intraoperative red blood cell transfusion was identified as an independent predictor of LAP monitoring strategy failure. Ninety-day postoperative mortality was not significantly different between groups (1.5% vs 8.3%, P = .12).Conclusions\n\nContinuous postoperative monitoring of LAP after DLTx for PH was associated with improved early outcomes. This strategy may help reduce the incidence of severe postoperative complications in this high-risk population.",
  "abstract_shown": true,
  "affiliations": [
    "Université Paris-Saclay, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Faculté de Médecine, Le Kremlin-Bicêtre, France.",
    "INSERM UMR_S 1358, Marie Lannelongue Hospital, FHU André Cournand, Le Plessis Robinson, France.",
    "Department of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Le Plessis Robinson, France.",
    "Department of Respiratory and Intensive Care Medicine, AP-HP, ERN-LUNG, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.",
    "Department of Anesthesiology, Marie Lannelongue Hospital, Le Plessis Robinson, France.",
    "Intensive Care Unit, Marie Lannelongue Hospital, Le Plessis Robinson, France."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Olaf Mercier"
    },
    {
      "affs": [
        2
      ],
      "name": "Luce Dedier"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Justin Issard"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Laurent Savale"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Emeline Plubel"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Dominique Fabre"
    },
    {
      "affs": [
        2
      ],
      "name": "Delphine Mitilian"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jean Baptiste Menager"
    },
    {
      "affs": [
        4
      ],
      "name": "Thibaut Genty"
    },
    {
      "affs": [
        5
      ],
      "name": "Iolanda Ion"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jérôme Le Pavec"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Elie Fadel"
    },
    {
      "name": "Marie Lannelongue Transplantation Program"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cgqdc7wpczqy3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xjon.2026.101967",
  "fulltext_url": "https://europepmc.org/articles/PMC13711168",
  "id": "cgqdc7wpczqy3",
  "issns": [
    "2666-2736"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948114",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Thoracic: Lung Transplantation"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13711168?pdf=render",
  "pmcid": "PMC13711168",
  "pmid": "42948114",
  "published": "2026-07-16",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/cgqdc7wpczqy3.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:36Z",
      "native_id": "MED:42948114",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948114"
    },
    {
      "first_seen": "2026-10-31T12:21:59Z",
      "native_id": "PMC13711168",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xjon.2026.101967"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Left atrial pressure continuous monitoring improves early postoperative outcomes after double-lung transplantation for pulmonary hypertension.",
  "title_text": "Left atrial pressure continuous monitoring improves early postoperative outcomes after double-lung transplantation for pulmonary hypertension.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:59Z",
  "url": "https://research.draconitic.com/paper/cgqdc7wpczqy3",
  "venue": "JTCVS open",
  "versions": []
}