{
  "abstract": "Polydopamine (PDA) exhibits unique advantages in the treatment of oxidative damage owing to its melanin-mimetic structure, abundant redox-active functional groups, and excellent biocompatibility. Distinct from conventional antioxidant molecules, PDA-based nanoplatforms can efficiently eliminate reactive oxygen species (ROS) via hydrogen atom transfer and electron transfer mechanisms, while relying on the dynamic redox cycling of catechol/quinone moieties to achieve sustained antioxidant activity. However, systematic summaries of PDA-based antioxidant nanoplatforms remain relatively limited. Therefore, this review provides a comprehensive overview of the antioxidant mechanisms of PDA and its associated physicochemical properties, with particular emphasis on the design strategies of diverse PDA-based nanoplatforms, including solid, mesoporous, hollow, doped, and coated architectures, as well as the effects of structural features, particle size, composition, and surface charge on their antioxidant performance. In addition, recent research progress is systematically categorized around core pathological challenges, including breaking ROS-inflammation feedback loops, overcoming biological delivery barriers, remodeling regenerative microenvironments, and regulating programmed cell death.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China",
    "Department of Microbial and Biochemical Pharmacy, School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China",
    "Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China. 20101233@cmu.edu.cn",
    "Department of Pharmacy, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, People's Republic of China. longwan@cmu.edu.cn",
    "Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. qinfuzhao@syphu.edu.cn",
    "Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang, 110016, People's Republic of China. qinfuzhao@syphu.edu.cn"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhilin Wang",
      "orcid": "0000-0002-0188-0332"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhu Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Luming Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyi Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuaipeng Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Donghua Di"
    },
    {
      "affs": [
        2
      ],
      "name": "Hao Ju",
      "orcid": "0000-0002-1928-2605"
    },
    {
      "affs": [
        3
      ],
      "name": "Long Wan"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Qinfu Zhao",
      "orcid": "0000-0002-9293-5481"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cgwt7hgzwxakq.bib",
  "cited_by": 12,
  "doi": "10.1007/s40820-026-02205-9",
  "fulltext_url": null,
  "id": "cgwt7hgzwxakq",
  "issns": [
    "2150-5551",
    "2311-6706"
  ],
  "landing_url": "https://doi.org/10.1007/s40820-026-02205-9",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Advanced Nanomaterials in Catalysis"
    ]
  ],
  "openalex": "W7161566194",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s40820-026-02205-9.pdf",
  "pmcid": "PMC13184132",
  "pmid": "42149371",
  "published": "2026-05-18",
  "publisher": "Springer Science+Business Media",
  "ris": "https://research.draconitic.com/paper/cgwt7hgzwxakq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:27:00Z",
      "native_id": "W7161566194",
      "source": "openalex",
      "url": "https://doi.org/10.1007/s40820-026-02205-9"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Advanced Nanomaterials in Catalysis",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Advances in Polydopamine-Based Nanoplatforms: Antioxidant Mechanisms and Applications in Oxidative Stress-Mediated Diseases",
  "title_text": "Advances in Polydopamine-Based Nanoplatforms: Antioxidant Mechanisms and Applications in Oxidative Stress-Mediated Diseases",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:22Z",
  "url": "https://research.draconitic.com/paper/cgwt7hgzwxakq",
  "venue": "Nano-Micro Letters",
  "versions": []
}