{
  "abstract": "We report a case of ALK-rearranged pulmonary large-cell neuroendocrine carcinoma (LCNEC) with brain metastases and radiologically suspected leptomeningeal involvement, successfully treated with first-line lorlatinib. A 58-year-old woman was diagnosed with LCNEC, and molecular testing revealed an EML4-ALK fusion. Lorlatinib achieved a partial response, with regression of the primary lesion, brain metastases, and suspected leptomeningeal lesions. Our literature review showed that ALK-positive LCNEC occurs more often in younger, female, and never- or light-smoking patients. In such cases, molecular testing should be actively pursued. In LCNEC harboring actionable driver alterations, molecularly guided treatment, as used for NSCLC, may be a reasonable option.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Yoshio Nakano"
    },
    {
      "name": "Kazuya Nishimura"
    },
    {
      "name": "Hiroka Serizawa"
    },
    {
      "name": "Yusuke Kuze"
    },
    {
      "name": "Gen Masuda"
    },
    {
      "name": "Norio Okamoto"
    },
    {
      "name": "Iwao Gohma"
    },
    {
      "name": "Yumiko Yasuhara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cgz7t6y0nqqyk.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7727-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7727-26/_article",
  "id": "cgz7t6y0nqqyk",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7727-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2740|Lung Cancer Treatments and Mutations"
    ]
  ],
  "openalex": "W7203704202",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7727-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cgz7t6y0nqqyk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7727-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7727-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Lung Cancer Treatments and Mutations",
      "subfield": "general"
    }
  ],
  "title": "First-Line Lorlatinib for ALK-Rearranged Pulmonary Large-Cell Neuroendocrine Carcinoma with Brain Metastases and Suspected Leptomeningeal Involvement: A Case Report and Literature Review",
  "title_text": "First-Line Lorlatinib for ALK-Rearranged Pulmonary Large-Cell Neuroendocrine Carcinoma with Brain Metastases and Suspected Leptomeningeal Involvement: A Case Report and Literature Review",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/cgz7t6y0nqqyk",
  "venue": "Internal Medicine",
  "versions": []
}