{
  "abstract": "Speech processing involves a hierarchy of cognitive layers from low-level phonetic to high-level semantic representations. However, interactions are not only feed-forward; feedback mechanisms are crucial for real-time, accurate speech recognition. Yet how distant levels interface during speech processing remains unclear. Here, we analyzed intracortical recordings from 624 neurons across three human participants implanted with microelectrode arrays in the anterior superior temporal gyrus during an auditory semantic categorization task and natural speech perception. We identified distinct neural subspaces, or manifolds, for lexico-semantic and phonetic features, with a functional separation of the corresponding low-dimensional dynamics. We contrasted a bottom-up cumulative and a top-down semantic hypothesis on phonetic-semantic temporal alignment, and found phonetic alignment to word-level semantic representations, signaling top-down prediction. These effects were consistent across participants at the spiking level, and remained undetected in adjacent ECoG recordings. These findings demonstrate the reorganization of neuronal population dynamics supporting phonetic representations during semantic prediction.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland",
    "Carney Institute for Brain Science, Brown University, Providence, RI, USA",
    "Department of Neuroscience, Brown University, Providence, RI, USA",
    "Department of Neuroscience & Radiology, University of California San Diego, La Jolla, CA, USA",
    "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA",
    "Institut Pasteur, Université Paris Cité, Hearing Institute, Paris, France",
    "Institute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich, Switzerland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pavo Orepić",
      "orcid": "0000-0001-6965-7578"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Wilson Truccolo",
      "orcid": "0000-0002-4444-3917"
    },
    {
      "affs": [
        3
      ],
      "name": "Eric Halgren",
      "orcid": "0000-0001-5926-6872"
    },
    {
      "affs": [
        4
      ],
      "name": "Sydney S. Cash",
      "orcid": "0000-0002-4557-6391"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Anne‐Lise Giraud",
      "orcid": "0000-0002-1261-3555"
    },
    {
      "affs": [
        6
      ],
      "name": "Timothée Proix",
      "orcid": "0000-0003-4750-9915"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/che0a307rmgy5.bib",
  "cited_by": 6,
  "doi": "10.1038/s41467-026-77942-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13724739",
  "id": "che0a307rmgy5",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77942-x",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.scco"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.scco.neur"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "hal",
      "2.sdv.neu.sc"
    ],
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2805|Neurobiology of Language and Bilingualism"
    ]
  ],
  "openalex": "W7219129775",
  "pdf_url": "https://pasteur.hal.science/pasteur-05783534/document",
  "pmcid": "PMC10634964",
  "pmid": "37961305",
  "published": "2026-10-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/che0a307rmgy5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-77942-x",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77942-x"
    },
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "pasteur-05783534",
      "source": "hal",
      "url": "https://pasteur.hal.science/pasteur-05783534v1"
    },
    {
      "first_seen": "2026-10-30T13:26:53Z",
      "native_id": "W7219129775",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41467-026-77942-x"
    },
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42967905",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42967905"
    },
    {
      "first_seen": "2026-11-04T12:23:15Z",
      "native_id": "PMC13724739",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77942-x"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.scco.neur",
      "subfield": "neuroscience"
    }
  ],
  "title": "Top-down semantic predictions align phonetic neuronal dynamics in human superior temporal gyrus",
  "title_text": "Top-down semantic predictions align phonetic neuronal dynamics in human superior temporal gyrus",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:21:27Z",
  "url": "https://research.draconitic.com/paper/che0a307rmgy5",
  "venue": "Nature Communications",
  "versions": []
}