{
  "abstract": "Despite advances in the acute clinical management of severe traumatic brain injuries (TBIs), treating injury-derived secondary pathogenesis remains challenging. We demonstrate intracerebroventricular (I.C.V.) administration of clindamycin alleviates TBI secondary pathogenesis in both focal and diffuse murine models of brain injury. I.C.V. administration of clindamycin increased the motility of ependymal cilia, which line the ventricles and spinal canal, by 30 to 60%, which correlated with interstitial brain fluid drainage through the cortex (r > 0.9 Pearson, n = 4 compounds tested). I.C.V. clindamycin treatment post-TBI also restored the blood–brain barrier (BBB), decreased lesion size, and lowered serum levels of glial fibrillary acidic protein by 2.8-fold. Consistent with these data, a novel objective recognition test revealed an improvement in recognition memory in brain-injured mice treated with clindamycin. These collective findings reveal a counterintuitive finding that I.C.V. clindamycin enhances drainage of toxins from the brain while simultaneously restoring the BBB, potentially providing a new solution for alleviating secondary pathogenesis in brain-injured patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, The University of Texas at Austin, Austin, TX 78712",
    "Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712",
    "Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX 78712",
    "Cancer Research Center, The University of Texas at Austin, Austin, TX 78712",
    "Department of Diagnostic Medicine, The University of Texas at Austin, Austin, TX 78712",
    "Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030",
    "Department of Neurology, The University of Texas at Austin, Austin, TX 78712",
    "Department of Psychology, The University of Texas at Austin, Austin, TX 78712",
    "Mulva Clinic for the Neurosciences, The University of Texas at Austin, Austin, TX 78712"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Landon S. Ashby",
      "orcid": "0000-0001-8359-7399"
    },
    {
      "affs": [
        0
      ],
      "name": "Megan G. Crowe",
      "orcid": "0009-0003-3409-9774"
    },
    {
      "affs": [
        0
      ],
      "name": "Daveraj Chakravarty",
      "orcid": "0000-0002-7629-8873"
    },
    {
      "affs": [
        0
      ],
      "name": "Sanjeev Medam"
    },
    {
      "affs": [
        0
      ],
      "name": "Gabriel Frampton",
      "orcid": "0000-0002-8467-5077"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ayesha B. Das",
      "orcid": "0000-0001-5782-8894"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "David A. Hormuth",
      "orcid": "0000-0002-9643-1694"
    },
    {
      "affs": [
        1,
        2,
        3,
        4,
        5
      ],
      "name": "Thomas E. Yankeelov",
      "orcid": "0000-0001-6201-3913"
    },
    {
      "affs": [
        0
      ],
      "name": "Vincent Y. C. Wang"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Linda J. Noble-Haeusslein",
      "orcid": "0000-0002-2653-7047"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Benjamin J. Umlauf",
      "orcid": "0009-0000-3187-1026"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/chhryqeegz8v8.bib",
  "cited_by": 0,
  "doi": "10.1073/pnas.2536755123",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732206/",
  "id": "chhryqeegz8v8",
  "issns": [
    "0027-8424",
    "1091-6490"
  ],
  "landing_url": "https://doi.org/10.1073/pnas.2536755123",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "424"
    ],
    [
      "heading",
      "Biological Sciences"
    ],
    [
      "heading",
      "Neuroscience"
    ],
    [
      "openalex",
      "2728|Traumatic Brain Injury and Neurovascular Disturbances"
    ]
  ],
  "openalex": "W7223840429",
  "pdf_url": null,
  "pmcid": "PMC13732206",
  "pmid": "42945250",
  "published": "2026-10-27",
  "publisher": "National Academy of Sciences",
  "ris": "https://research.draconitic.com/paper/chhryqeegz8v8.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:14Z",
      "native_id": "PMC13732206",
      "source": "pmc",
      "url": "https://doi.org/10.1073/pnas.2536755123"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Intraventricular clindamycin enhances interstitial brain fluid drainage and the blood–brain barrier after a traumatic brain injury",
  "title_text": "Intraventricular clindamycin enhances interstitial brain fluid drainage and the blood–brain barrier after a traumatic brain injury",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:14Z",
  "url": "https://research.draconitic.com/paper/chhryqeegz8v8",
  "venue": "Proceedings of the National Academy of Sciences of the United States of America",
  "versions": []
}