{
  "abstract": "The rise in obesity prevalence has been linked to overconsumption of high-sugar containing food and beverages. Recent evidence suggests that chronic sucrose consumption leads to changes in serotonergic neuroplasticity within the neural circuits involved in feeding control. Although there is a relationship between serotonin signalling in the brain and diet-induced obesity, the specific serotonin (5-HT) receptors or pathways involved remain unknown. The 5-HT1A receptor subtype plays a role in regulating mood, anxiety, and appetite, and has been associated with reversing addiction to substances of abuse. However, the respective role of 5-HT1A auto- vs heteroreceptors in sucrose consumption has not been examined. Mice were given controlled access to either 5%, 10% or 25% w/v sucrose, or water as a control, for 12 weeks using the well-established “drinking in the dark” protocol (n = 6–8 mice per group). Ligands selectively targeting 5-HT1A auto- and/or heteroreceptors (NLX-112, unbiased 5-HT1A receptor agonist; NLX-101, preferential heteroreceptor agonist; F13714, preferential autoreceptor agonist) were administered i.p. acutely after 6 and 12 weeks of sucrose consumption. The specific involvement of 5-HT1A receptors in these effects was verified by blockade with the selective 5-HT1A receptors antagonist WAY-100,635. The specific subpopulation of 5-HT1A receptors involved in sucrose consumption was dependent on the concentration of sucrose solution and the duration of exposure to sucrose (6 weeks vs 12 weeks). Long-term sucrose consumption leads to accentuated 5-HT1A autoreceptor function. Thus, targeting 5-HT1A autoreceptors might represent an effective therapeutic strategy to combat the rise in obesity resulting from the overconsumption of high-sugar diet.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Kate Beecher"
    },
    {
      "name": "Joshua Wang"
    },
    {
      "name": "Fatemeh Chehrehasa"
    },
    {
      "name": "Ronan Depoortere"
    },
    {
      "name": "Mark Varney"
    },
    {
      "name": "Adrian Newman-Tancredi"
    },
    {
      "name": "Selena Bartlett"
    },
    {
      "name": "Arnauld Belmer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/chhx8pb8wwgpt.bib",
  "cited_by": 5,
  "doi": "10.1016/j.biopha.2022.112699",
  "fulltext_url": null,
  "id": "chhx8pb8wwgpt",
  "issns": [
    "0753-3322",
    "1950-6007"
  ],
  "landing_url": "https://hal.science/hal-05795102v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "hal",
      "2.sdv.neu.nb"
    ],
    [
      "openalex",
      "2804|Neurotransmitter Receptor Influence on Behavior"
    ]
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  "openalex": "W4211093776",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S0753332222000877/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/chhx8pb8wwgpt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:54Z",
      "native_id": "hal-05795102",
      "source": "hal",
      "url": "https://hal.science/hal-05795102v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    }
  ],
  "title": "Dissecting the contribution of 5-HT1A auto- and heteroreceptors in sucrose overconsumption in mice",
  "title_text": "Dissecting the contribution of 5-HT1A auto- and heteroreceptors in sucrose overconsumption in mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:54Z",
  "url": "https://research.draconitic.com/paper/chhx8pb8wwgpt",
  "venue": "Biomedicine and Pharmacotherapy",
  "versions": []
}