{
  "abstract": "Introduction: Depression is associated with dysregulation of neuroendocrine, immune, and gut -brain axis pathways. Exercise is an effective non-pharmacological intervention; however, poor motivation and fatigue limit adherence in patients with depression.\n\nMethods: We investigated a novel passive exercise modality, low-frequency passive vertical oscillation assisted by elastic ropes (LF-PVO-ER), in a chronic unpredictable mild stress (CUMS) rat model.\n\nResults: LF-PVO-ER significantly improved depressive-like behaviors, including anhedonia and behavioral despair. Alongside these behavioral improvements, increases were observed in serum serotonin and brain-derived neurotrophic factor (BDNF), along with reductions in serum corticosterone, inflammatory markers (IL-6, TNF), and lipopolysaccharide (LPS). Histological analysis revealed attenuation of hippocampal and colonic injury. 16S rRNA sequencing showed partial restoration of CUMS-induced gut microbiota dysbiosis, as reflected by increased diversity and enrichment of short-chain fatty acid (SCFA)-associated genera. Untargeted metabolomics revealed changes in amino acid, lipid, and bile acid metabolism. Integrated analyses indicated coordinated associations among gut microbiota, metabolites, and neuroimmune markers.\n\nConclusion: These findings suggest that LF-PVO-ER may exert antidepressant-like effects through multiple pathways involving neuroendocrine function, inflammatory responses, and gut microbiota -metabolite interactions, supporting its potential as a passive exercise strategy for depression intervention.",
  "abstract_shown": true,
  "affiliations": [
    "School of Basic Medicine, Gansu Medical College, Pingliang, China",
    "Key Laboratory of Microbial Cohort and Multi-omics Research in Gansu Province, Gansu Medical College, Pingliang, China",
    "Pingliang Mental Health Center, Pingliang, China",
    "School of Clinical Medicine, Gansu Medical College, Pingliang, China",
    "Affiliated Hospital of Gansu Medical College, Pingliang, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rong Gao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenjing Pu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yifei Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Liqiong Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yan Zhao"
    },
    {
      "affs": [
        3
      ],
      "name": "Hao Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Li Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Nan Guan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hongen Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cj4t08ah534r9.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1928978",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696317/",
  "id": "cj4t08ah534r9",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://doi.org/10.3389/fimmu.2026.1928978",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2736|Treatment of Major Depression"
    ]
  ],
  "openalex": "W7221433709",
  "pdf_url": "https://europepmc.org/articles/PMC13696317?pdf=render",
  "pmcid": "PMC13696317",
  "pmid": "42935785",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cj4t08ah534r9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "PMC13696317",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1928978"
    },
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1928978",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1928978/full"
    },
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42935785",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935785"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Treatment of Major Depression",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Low-frequency passive mechanical stimulation produces antidepressant-like effects in rats involving gut–brain axis modulation",
  "title_text": "Low-frequency passive mechanical stimulation produces antidepressant-like effects in rats involving gut–brain axis modulation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:40Z",
  "url": "https://research.draconitic.com/paper/cj4t08ah534r9",
  "venue": "Frontiers in Immunology",
  "versions": []
}