{
  "abstract": "Compartment syndrome (CS) causes ischaemia–reperfusion-related skeletal muscle injury, and adjunct pharmacological strategies may reduce secondary tissue damage. This study compared silibinin and deferoxamine in a rat model of CS. Thirty-six male Sprague–Dawley rats were randomised into six groups (n = 6). CS was induced by applying 140 mmHg external cuff pressure to the right hind limb for 3 h, followed by reperfusion. Animals received vehicle, silibinin (200 mg/kg/day by oral gavage), or deferoxamine (100 mg/kg/day intraperitoneally) until Day 4 or Day 14. CS + vehicle rats received oral distilled water and intraperitoneal 0.9% NaCl without active drug; active treatment groups received route-matched vehicle through the alternative route. Functional performance was assessed using the inclined plane test, and gastrocnemius muscles were examined using hematoxylin-eosin, Masson’s trichrome, Pax7, and Myogenin staining. At Day 14, both treatment groups showed higher inclined plane performance and lower myofiber necrosis and collagen-associated remodeling scores than the CS + vehicle group. Pax7 and Myogenin showed distinct patterns of expression between the Day 4 and Day 14 cohorts. Overall, silibinin and deferoxamine were associated with lower histopathological injury and higher functional performance in the Day 14 groups than in the corresponding Day 4 groups in this experimental CS model, while Pax7 and Myogenin findings indicated differences in myogenic marker expression between the Day 4 and Day 14 cohorts rather than definitive regenerative kinetics.",
  "abstract_shown": true,
  "affiliations": [
    "Orthopaedics and Traumatology Clinic, Sultanbeyli State Hospital",
    "Department of Orthopaedics and Traumatology, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, Marmara University",
    "Department of Pathology, Marmara University Faculty of Medicine, Marmara University Pendik Training and Research Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Berk Koncalioglu"
    },
    {
      "affs": [
        1
      ],
      "name": "Çağrı Ata Mutlu"
    },
    {
      "affs": [
        2
      ],
      "name": "Emine Çeşmecioğlu-Karavin"
    },
    {
      "affs": [
        1
      ],
      "name": "Batuhan Gencer"
    },
    {
      "affs": [
        1
      ],
      "name": "Osman Mert Topkar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cj8brvjkzkkw8.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-69079-0",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-69079-0",
  "id": "cj8brvjkzkkw8",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-69079-0",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2746|Muscle and Compartmental Disorders"
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  "openalex": "W7204791099",
  "pdf_url": "https://www.nature.com/articles/s41598-026-69079-0_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/cj8brvjkzkkw8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:57Z",
      "native_id": "3f42a04359aa4b94b90f343b994e10fc",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-69079-0"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Muscle and Compartmental Disorders",
      "subfield": "surgery"
    }
  ],
  "title": "Comparative effects of silibinin and deferoxamine on skeletal muscle injury and regeneration in a rat model of compartment syndrome",
  "title_text": "Comparative effects of silibinin and deferoxamine on skeletal muscle injury and regeneration in a rat model of compartment syndrome",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:57Z",
  "url": "https://research.draconitic.com/paper/cj8brvjkzkkw8",
  "venue": "Scientific Reports",
  "versions": []
}