{
  "abstract": "Objectives To estimate the prevalence of exertional dyspnea in a French cohort of patients with severe asthma and to explore associated factors, with a focus on biologics. Methods RAMSES is a French, multicenter, prospective cohort of patients with severe asthma. The primary outcome was exertional dyspnea defined by a modified Medical Research Council (mMRC) score ≥2. Secondary outcomes were mMRC score ≥1 and ≥ 3. To study factors associated with exertional dyspnea, logistic regressions were performed. We hypothesized that the potential effect of biologics on exertional dyspnea relied on improved asthma control, and explored it through a mediation model. Results A total of 569 participants from the RAMSES cohort were included. Among them, 360 (65.5%) had uncontrolled asthma and 307 (54.1%) were treated with biologics. The prevalence of exertional dyspnea defined by an mMRC score ≥1, ≥2 and ≥ 3 was respectively 73.8 [70.2; 77.4] %, 48.5 [44.4; 52.6] % and 21.6 [18.2; 25] %. The Asthma Control Test (ACT) score was the factor most strongly associated with exertional dyspnea (mMRC score ≥2) (OR = 0.8 [0.74; 0.86] for 1-point increase). Biologic therapy was associated with a lower rate of exertional dyspnea (OR = 0.46 [0.25–0.84]), with the effect largely mediated by an improvement in the ACT score (mediation ratio: 63.4% [5.1–254.2]) Conclusion Our results highlight the high prevalence of dyspnea-related disability in severe asthma, justifying considering this treatable trait as a priority therapeutic goal. Exertional dyspnea was associated with uncontrolled asthma and biologics, primarily through asthma control.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Jonathan Giovannelli"
    },
    {
      "name": "Thierry Perez"
    },
    {
      "name": "Gilles Garcia"
    },
    {
      "name": "Gilles Devouassoux"
    },
    {
      "name": "Stéphanie Fry"
    },
    {
      "name": "Arnaud Bourdin"
    },
    {
      "name": "Pascal Chanez"
    },
    {
      "name": "Philippe Bonniaud"
    },
    {
      "name": "Amel Boudjemaa"
    },
    {
      "name": "Christel Saint-Raymond"
    },
    {
      "name": "Antoine Beurnier"
    },
    {
      "name": "Nathalie Bautin"
    },
    {
      "name": "Candice Estellat"
    },
    {
      "name": "Camille Taillé"
    },
    {
      "name": "Cécile Chenivesse"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cjbravwhqck9z.bib",
  "cited_by": 0,
  "doi": "10.1016/j.rmed.2026.109239",
  "fulltext_url": null,
  "id": "cjbravwhqck9z",
  "issns": [
    "0954-6111",
    "1532-3064"
  ],
  "landing_url": "https://hal.science/hal-05838833v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7223252202",
  "pdf_url": "https://hal.science/hal-05838833/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/cjbravwhqck9z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "hal-05838833",
      "source": "hal",
      "url": "https://hal.science/hal-05838833v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "Prevalence and factors associated with exertional dyspnea in severe asthma: data at inclusion from the French RAMSES cohort",
  "title_text": "Prevalence and factors associated with exertional dyspnea in severe asthma: data at inclusion from the French RAMSES cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:01Z",
  "url": "https://research.draconitic.com/paper/cjbravwhqck9z",
  "venue": "Respiratory Medicine",
  "versions": []
}