{
  "abstract": "The sensitive and real-time detection of Luteinizing Hormone (LH) is essential for monitoring reproductive health and supporting assisted reproductive technologies (ART). In this study, LH was detected within the physiological range using an electrochemical aptasensor integrated into a microfluidic platform. Quantification was achieved via cyclic voltammetry in PBS and 10% diluted horse serum over a concentration range of 0.2 pM to 10 nM. The microfluidic device enabled rapid analysis with a target detection protocol of approximately 30 minutes, making it suitable for near real-time applications. To assess performance in more complex biological matrices, the sensor was also implemented in 20% diluted spiked blood serum and in 25% diluted spiked whole blood with LH. While current responses were decreased due to matrix interference, a clear, concentration-dependent signal was still observed, confirming the sensor's robustness and reliability under given experimental conditions. These results demonstrate the sensor's potential for integration into portable, real-time diagnostic systems for hormone monitoring, particularly in ART and infertility diagnostics.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Hiu Mun Man"
    },
    {
      "name": "Marie-Charlotte Horny"
    },
    {
      "name": "Isabelle Le Potier"
    },
    {
      "name": "David Bouville"
    },
    {
      "name": "Téo Baptiste"
    },
    {
      "name": "Anne-Marie Haghiri- Gosnet"
    },
    {
      "name": "Brice Calvignac"
    },
    {
      "name": "Pierre-Emmanuel Bouet"
    },
    {
      "name": "Laurent Thouin"
    },
    {
      "name": "Jean Gamby"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cjdyqnrd1a24t.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": null,
  "id": "cjdyqnrd1a24t",
  "issns": [],
  "landing_url": "https://hal.science/hal-05772662v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "0.phys"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "0.spi"
    ],
    [
      "hal",
      "1.chim.theo"
    ],
    [
      "hal",
      "1.phys.phys"
    ],
    [
      "hal",
      "1.sdv.bio"
    ],
    [
      "hal",
      "1.spi.nano"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://hal.science/hal-05772662/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cjdyqnrd1a24t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:45Z",
      "native_id": "hal-05772662",
      "source": "hal",
      "url": "https://hal.science/hal-05772662v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.bio",
      "subfield": "systems-synthetic"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.theo",
      "subfield": "theoretical"
    },
    {
      "field": "physics",
      "origin": "hal:0.phys",
      "subfield": "general"
    }
  ],
  "title": "Novel aptasensor coupling electrochemistry and microfluidics for the detection of luteinising hormone in fertility monitoring",
  "title_text": "Novel aptasensor coupling electrochemistry and microfluidics for the detection of luteinising hormone in fertility monitoring",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:45Z",
  "url": "https://research.draconitic.com/paper/cjdyqnrd1a24t",
  "venue": "HAL",
  "versions": []
}