{
  "abstract": "This study demonstrates that the metabolic phenotypes induced by 4-vinylcyclohexene diepoxide (VCD)-induced ovarian failure in rodents, used as an experimental model of menopause, strongly depend upon diet formulation. VCD-treated mice fed a corn/soy-based diet (PicoLab 5L0D) exhibited suppressed resting and total energy expenditures and increased adiposity, which parallels effects of menopause documented in humans. In contrast, VCD failed to induce such phenotypes in mice fed a wheat/corn-based diet (Inotiv 2920x).",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA",
    "Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI, USA",
    "Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI, USA",
    "Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA",
    "Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA",
    "Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, WI, USA",
    "Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Natalia M. Mathieu"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Samuel B.R. Lawton"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Margaret M. Dorrington"
    },
    {
      "affs": [
        3
      ],
      "name": "Connie C. Grobe"
    },
    {
      "affs": [
        0
      ],
      "name": "Valerie W. Hole"
    },
    {
      "affs": [
        0
      ],
      "name": "Kelsey K. Wackman"
    },
    {
      "affs": [
        4
      ],
      "name": "Henry Bordas-Murphy"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Julie K. Freed"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Jeffrey L. Segar"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pablo Nakagawa"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Curt D. Sigmund"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gary C. Mouradian"
    },
    {
      "affs": [
        0,
        1,
        5,
        6
      ],
      "name": "Justin L. Grobe"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "John J. Reho"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cje6nxv2mh5bm.bib",
  "cited_by": 0,
  "doi": "10.1152/ajpregu.00321.2025",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13718423/",
  "id": "cje6nxv2mh5bm",
  "issns": [
    "0363-6119",
    "1522-1490"
  ],
  "landing_url": "https://doi.org/10.1152/ajpregu.00321.2025",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2712|Menopause: Health Impacts and Treatments"
    ]
  ],
  "openalex": "W7215090251",
  "pdf_url": null,
  "pmcid": "PMC13718423",
  "pmid": "42821472",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cje6nxv2mh5bm.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:27Z",
      "native_id": "PMC13718423",
      "source": "pmc",
      "url": "https://doi.org/10.1152/ajpregu.00321.2025"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Menopause: Health Impacts and Treatments",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Diet Composition Modifies Cardiometabolic Phenotype Development in the 4-Vinylcyclohexene Dioxide (VCD) Ovarian Failure Model of Menopause",
  "title_text": "Diet Composition Modifies Cardiometabolic Phenotype Development in the 4-Vinylcyclohexene Dioxide (VCD) Ovarian Failure Model of Menopause",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:27Z",
  "url": "https://research.draconitic.com/paper/cje6nxv2mh5bm",
  "venue": "American journal of physiology. Regulatory, integrative and comparative physiology",
  "versions": []
}