{
  "abstract": "Background/Objectives: Albuminuria is an early marker of kidney damage and an independent predictor of adverse outcomes, making its reduction a key therapeutic goal. Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, has demonstrated renal and cardiovascular benefits in patients with diabetic kidney disease (DKD), although the magnitude of the antiproteinuric response may vary in clinical practice. This post hoc analysis aimed to characterize the six-month antiproteinuric response to finerenone and to descriptively explore baseline clinical and treatment characteristics across response categories in the FINDKDLATAM cohort. Methods: A subgroup analysis was performed on a real-world, multicenter, retrospective, observational study that included patients from the FINDKDLATAM study who had urinary albumin-to-creatinine ratio (UACR) measurements taken at baseline and six months. Patients were classified as absolute responders (≥50% reduction in UACR), partial responders (30-49% reduction), and non-responders (<30% reduction or no reduction in UACR) at six months of follow-up. Sociodemographic, clinical, biochemical, therapeutic, and safety variables were analyzed. Results: Of the 347 patients included in the original cohort, 334 had complete UACR data at six months and were included in the analysis. Of these, 80.2% (n = 268) were absolute responders, 11.7% (n = 39) partial responders, and 8.1% (n = 27) non-responders. Median UACR decreased from 350.7 to 67.0 mg/g among absolute responders and from 240.5 to 143.0 mg/g among partial responders (both p < 0.0001), whereas no significant change was observed among non-responders. No baseline clinical characteristic consistently distinguished responders from non-responders. Serum potassium increased during follow-up, particularly among non-responders. Conclusions: In this retrospective Latin American cohort, most patients experienced a reduction in UACR after six months of finerenone treatment. However, the uncontrolled observational design, concomitant therapies, UACR variability, and regression to the mean preclude attributing these changes exclusively to finerenone. These exploratory findings do not support selecting patients according to a particular responder phenotype but rather support prescribing finerenone according to currently approved clinical criteria. Prospective studies with adjusted analyses are needed to identify independent predictors of response.",
  "abstract_shown": true,
  "affiliations": [
    "Latin American Society of Nephrology and Hypertension (SLANH), Panamá City 0801, Panama.",
    "Colombian Association of Nephrology and Arterial Hypertension, Bogota 110221, Colombia.",
    "Department of Nephrology, Faculty of Medicine, Simón Bolívar University of Barranquilla, Barranquilla 080001, Colombia.",
    "Department of Nephrology, Hospital Central de la Defensa Gómez Ulla, 28047 Madrid, Spain.",
    "Department of Medicine and Medical Specialties, Faculty of Medicine, Alcala University, 28805 Madrid, Spain.",
    "Faculty of Medicine, Department of Nephrology, University of San Carlos of Guatemala (USAC), Guatemala City 01011, Guatemala.",
    "Department of Epidemiology, El Rosario University, Bogota 111221, Colombia.",
    "Medical and Surgical Research, GIBACUS Research Group, Sinú University EBZ, Cartagena Campus, Cartagena 130010, Colombia.",
    "Faculty of Nursing, Health Services Administration Program, University of Cartagena, Cartagena 130005, Colombia.",
    "Department of Nephrology, Del Valle Hospital, Catholic University of Honduras, San Pedro Sula 21102, Honduras.",
    "Department of Nephrology, Dr. Abel Gilbert Pontón Hospital of Guayaquil, Ministry of Public Health, O'Connors, Guayaquil 090104, Ecuador.",
    "Department of Nephrology, Honduran Institute of Social Security, North Region, San Pedro Sula 21102, Honduras.",
    "Department of Nephrology, Bendaña Hospital, San Pedro Sula 21102, Honduras.",
    "Internal Medicine, Mario Catarino Rivas Hospital, San Pedro Sula 21102, Honduras.",
    "Department of Nephrology, Rafael Rodríguez Zambrano Hospital, Manta 130206, Ecuador.",
    "Department of Internal Medicine East, Faculty of Medicine, University of Chile, Providencia, Santiago 8320000, Chile.",
    "Department of Nephrology, Metropolitan Hospital of Santiago, Santiago de los Caballeros 51000, Dominican Republic.",
    "Department of Engineering, Faculty of Science and Engineering, Peruana Cayetano Heredia University, Lima 15012, Peru.",
    "Department of Nephrology, San Jose Maicao ESE Hospital, Maicao 442001, Colombia.",
    "Department of Internal Medicine, Faculty of Medicine, University of Cartagena, Cartagena 130005, Colombia.",
    "Department of Nephrology, Armed Forces Specialty Hospital Number 1, Quito City 170403, Ecuador.",
    "Department of Internal Medicine, University of Valle, Cali 760042, Colombia.",
    "Department of Nephrology, Davita Kidney Care, Barranquilla 080020, Colombia.",
    "Department of Nephrology, Hospital General de Fuerteventura, 35600 Puerto del Rosario, Spain.",
    "Department of Nephrology, Hospital Señora de Sonsoles, 05004 Avila, Spain.",
    "Surgery Department, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jorge Rico Fontalvo",
      "orcid": "0000-0002-2852-1241"
    },
    {
      "affs": [
        2
      ],
      "name": "María Raad Sarabia"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "José C De La Flor",
      "orcid": "0000-0001-9346-2279"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Vicente Sánchez Polo",
      "orcid": "0000-0003-3253-6363"
    },
    {
      "affs": [
        6
      ],
      "name": "Jenniffer Benavides Garcia",
      "orcid": "0000-0001-6687-4147"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Enrique Ramos Clason"
    },
    {
      "affs": [
        0,
        9
      ],
      "name": "Daniel Domínguez"
    },
    {
      "affs": [
        10
      ],
      "name": "Giovanny Mera Rebutti",
      "orcid": "0000-0002-5892-472X"
    },
    {
      "affs": [
        11
      ],
      "name": "Carlos Madrid Mancia"
    },
    {
      "affs": [
        9
      ],
      "name": "Rene Tabora López",
      "orcid": "0009-0003-4811-8067"
    },
    {
      "affs": [
        0,
        12,
        13
      ],
      "name": "Manuel Rocha Meza",
      "orcid": "0009-0003-4170-4047"
    },
    {
      "affs": [
        9
      ],
      "name": "Dany Tabora López",
      "orcid": "0009-0002-5620-5243"
    },
    {
      "affs": [
        14
      ],
      "name": "James J Muñoz Zambrano"
    },
    {
      "affs": [
        0,
        15
      ],
      "name": "Eduardo Lorca Herrera",
      "orcid": "0000-0002-3670-075X"
    },
    {
      "affs": [
        0,
        16
      ],
      "name": "Eliana Dina-Batlle"
    },
    {
      "affs": [
        17
      ],
      "name": "Michael Cieza Terrones",
      "orcid": "0000-0002-6558-7231"
    },
    {
      "affs": [
        1,
        18
      ],
      "name": "Alvaro Pedroza Pallares",
      "orcid": "0000-0001-7178-1906"
    },
    {
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        7,
        8,
        19
      ],
      "name": "Tomas Rodríguez Yánez"
    },
    {
      "affs": [
        20
      ],
      "name": "Washington Osorio"
    },
    {
      "affs": [
        21
      ],
      "name": "Alyi Arellano Cabeza"
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    {
      "affs": [
        1,
        22
      ],
      "name": "Juan Felipe Gutiérrez"
    },
    {
      "affs": [
        23
      ],
      "name": "Avinash Chandu Nanwani",
      "orcid": "0009-0002-0633-6325"
    },
    {
      "affs": [
        24,
        25
      ],
      "name": "Celia Rodríguez Tudero",
      "orcid": "0009-0006-9873-3043"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rodrigo Daza Arnedo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cjgx1n0bseaq3.bib",
  "cited_by": 0,
  "doi": "10.3390/clinpract16100174",
  "fulltext_url": "https://europepmc.org/articles/PMC13703580",
  "id": "cjgx1n0bseaq3",
  "issns": [
    "2039-7275",
    "2039-7283"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930360",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Chronic Kidney Disease and Diabetes"
    ]
  ],
  "openalex": "W7213974208",
  "pdf_url": "https://europepmc.org/articles/PMC13703580?pdf=render",
  "pmcid": "PMC13703580",
  "pmid": "42930360",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cjgx1n0bseaq3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930360",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930360"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Chronic Kidney Disease and Diabetes",
      "subfield": "general"
    }
  ],
  "title": "Antiproteinuric Response to Finerenone in Diabetic Kidney Disease: Responder and Non-Responder Subgroup Analysis of the FINDKDLATAM Study.",
  "title_text": "Antiproteinuric Response to Finerenone in Diabetic Kidney Disease: Responder and Non-Responder Subgroup Analysis of the FINDKDLATAM Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/cjgx1n0bseaq3",
  "venue": "Clinics and practice",
  "versions": []
}