{
  "abstract": "A woman in her late 70s presented with 14 months of refractory diarrhoea and 32% unintentional weight loss, meeting Global Leadership Initiative on Malnutrition criteria for severe malnutrition. Olmesartan, a component of fixed-dose combination antihypertensive therapy, went unrecognised during five encounters at three institutions. Targeted treatment of hypercalcaemia-related diarrhoea, pancreatic insufficiency, small intestinal bacterial overgrowth and suspected coeliac disease, together with empiric budesonide, failed. At the sixth encounter, component-level medication reconciliation identified olmesartan and revealed repeated improvement when olmesartan had not been administered during prior hospitalisations. Biopsies obtained during push enteroscopy were consistent with olmesartan-associated enteropathy, prompting permanent withdrawal (Naranjo score +9, definite adverse drug reaction). At 2-month follow-up, she had gained 4.8 kg with symptom resolution. Two obstacles contributed to the delay. Brand-name documentation of fixed-dose combination products obscured olmesartan on medication lists, and drug-induced diarrhoea was not considered during the evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Hospital Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA",
    "Division of Gastroenterology and Hepatology, The Johns Hopkins Hospital, Baltimore, Maryland, USA",
    "Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alinafe Mpanda",
      "orcid": "0009-0004-1352-0483"
    },
    {
      "affs": [
        1
      ],
      "name": "Mariame Sylla"
    },
    {
      "affs": [
        2
      ],
      "name": "Eric D Young",
      "orcid": "0000-0002-0014-1482"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cjn7dqd08brxb.bib",
  "cited_by": 0,
  "doi": "10.1136/bcr-2026-275970",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723749/",
  "id": "cjn7dqd08brxb",
  "issns": [
    "1757-790X"
  ],
  "landing_url": "https://doi.org/10.1136/bcr-2026-275970",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Gastroenterology"
    ],
    [
      "openalex",
      "2715|Celiac Disease Research and Management"
    ]
  ],
  "openalex": "W7223818874",
  "pdf_url": null,
  "pmcid": "PMC13723749",
  "pmid": "42946496",
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cjn7dqd08brxb.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:19Z",
      "native_id": "PMC13723749",
      "source": "pmc",
      "url": "https://doi.org/10.1136/bcr-2026-275970"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Celiac Disease Research and Management",
      "subfield": "general"
    }
  ],
  "title": "Olmesartan-associated enteropathy presenting as severe malnutrition",
  "title_text": "Olmesartan-associated enteropathy presenting as severe malnutrition",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:30Z",
  "url": "https://research.draconitic.com/paper/cjn7dqd08brxb",
  "venue": "BMJ Case Reports",
  "versions": []
}