{
  "abstract": "Background Pulmonary arterial hypertension (PAH) is a rare and severe condition that may be associated with exposure to certain drugs. Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor, has been classified as having a possible association with PAH, but data remain scarce. This study aimed to assess the potential link between bevacizumab exposure and PAH through complementary clinical, medico-administrative and pharmacovigilance databases. Methods We performed a multimodal investigation combining: 1) case identification from the French Pulmonary Hypertension (PH) Registry, 2) a population-based cohort analysis using the French National Health Data System (Système National des Données de Santé (SNDS)) and 3) a disproportionality analysis in the World Health Organization pharmacovigilance database (VigiBase). Clinical, haemodynamic and exposure data were reviewed in the French PH Registry; prevalence of PAH in patients exposed to bevacizumab was computed in the SNDS; and disproportionality analyses (information component (IC) values) were calculated in VigiBase. Results Seven cases of PAH temporally associated with bevacizumab were identified in the French PH Registry, most displaying predisposing conditions ( BMPR2 mutation, portal hypertension or COPD). In the SNDS cohort of 9964 PAH patients, 30 had prior bevacizumab exposure, with no increased incidence compared to the general population. In VigiBase, 21 PAH cases were reported with bevacizumab, yielding a modest disproportionality signal only under broad definitions (IC 0.4 (95% credibility interval 0.1–0.6)). Conclusions Across complementary data sources, there was no evidence of a causal association between exposure to bevacizumab and the development of PAH in adults. However, the effect of bevacizumab as a secondary trigger in predisposed individuals cannot be definitely or completely excluded.",
  "abstract_shown": true,
  "affiliations": [
    "Université de Lorraine, CHRU de Nancy, Pôle des Spécialités Médicales/Département de Pneumologie, Nancy, France",
    "Univ. Grenoble Alpes, Inserm U1300, HP2, Grenoble, France",
    "Department of Pharmacy, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France",
    "Université Rouen Normandie, GRHVN UR 3830, CHU Rouen, Department of Pulmonary, Thoracic Oncology and Respiratory Intensive Care, Rouen, France",
    "CCMR PulmoTension, Hôpital Robert Debré, CHU Reims, Reims, France",
    "Service des Maladies Respiratoires, Hôpital Haut Leveque CHU de Bordeaux Pessac, Pessac, France",
    "INSERM UMR_S1358, Pulmonary Hypertension: Pathophysiology and Novel Therapies, Hôpital Marie-Lannelongue and Hôpital Bicêtre, Le Kremlin-Bicêtre, France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Simon Valentin"
    },
    {
      "affs": [
        1
      ],
      "name": "Alex Hlavaty"
    },
    {
      "affs": [
        1
      ],
      "name": "Coline Brossat"
    },
    {
      "affs": [
        2
      ],
      "name": "Marie-Camille Chaumais"
    },
    {
      "affs": [
        3
      ],
      "name": "Élise Artaud-Macari"
    },
    {
      "affs": [
        4
      ],
      "name": "Pierre Mauran"
    },
    {
      "affs": [
        5
      ],
      "name": "Arnaud Maurac"
    },
    {
      "affs": [
        6
      ],
      "name": "Laurent Savale"
    },
    {
      "affs": [
        6
      ],
      "name": "Olivier Sitbon"
    },
    {
      "affs": [
        6
      ],
      "name": "Marc Humbert"
    },
    {
      "affs": [
        0
      ],
      "name": "Ari Chaouat"
    },
    {
      "affs": [
        1
      ],
      "name": "Charles Khouri"
    },
    {
      "affs": [
        6
      ],
      "name": "David Montani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ckd3ftp27d535.bib",
  "cited_by": 0,
  "doi": "10.1183/23120541.00209-2026",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656190/?tool=EBI",
  "id": "ckd3ftp27d535",
  "issns": [
    "2312-0541"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13656190",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2740|Pulmonary Hypertension Research and Treatments"
    ]
  ],
  "openalex": "W7154630969",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656190/pdf/?tool=EBI",
  "pmcid": "PMC13656190",
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "European Respiratory Society",
  "ris": "https://research.draconitic.com/paper/ckd3ftp27d535.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "PMC:PMC13656190",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13656190"
    },
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "hal-05828649",
      "source": "hal",
      "url": "https://univ-reims.hal.science/hal-05828649v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Multimodal investigation of the association between bevacizumab and pulmonary arterial hypertension",
  "title_text": "Multimodal investigation of the association between bevacizumab and pulmonary arterial hypertension",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:00Z",
  "url": "https://research.draconitic.com/paper/ckd3ftp27d535",
  "venue": "ERJ open research",
  "versions": []
}