{
  "abstract": "Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression meta-analysis of social behaviour from infancy to early adulthood, studying ~500,000 repeated measures in European-ancestry cohorts (N = 73,321). We modelled heterogeneity in single-variant associations across social domains (low prosocial behaviour and peer/social difficulties), multiple informants (parents, teachers and self-reports) and ages (2–29 years), identifying 6 associated loci, including variation within CADM2 (P = 2.51 × 10−9). Single nucleotide polymorphism-based heritability ranged from 2% to 7%, and the genetic architecture comprised 4 factors reflecting differences in either social domains or informants. Polygenic scores (N = 16,305) accurately predicted contextual variation in independent cohorts, with some cross-ancestry transferability. Context-specific patterns of genetic correlations, particularly when estimating the developmental onset of associations, offer opportunities to disentangle shared trajectories linking social behaviour with later-life and mental health outcomes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 95,
  "authors": [
    {
      "name": "Lucía de Hoyos"
    },
    {
      "name": "Fenja Schlag"
    },
    {
      "name": "Sanjeevan Jahagirdar"
    },
    {
      "name": "Elizabeth C Corfield"
    },
    {
      "name": "Andrea G Allegrini"
    },
    {
      "name": "Danielle Admiraal"
    },
    {
      "name": "Eveline L de Zeeuw"
    },
    {
      "name": "Ilja M Nolte"
    },
    {
      "name": "Natalia Llonga"
    },
    {
      "name": "Alexander Neumann"
    },
    {
      "name": "Katherine Lange"
    },
    {
      "name": "Simone van den Bedem"
    },
    {
      "name": "Ebba Du Rietz"
    },
    {
      "name": "Ehsan Motazedi"
    },
    {
      "name": "Else Eising"
    },
    {
      "name": "Nicole y T Ng"
    },
    {
      "name": "Teemu Palviainen"
    },
    {
      "name": "Carol A Wang"
    },
    {
      "name": "Elisabeth Thiering"
    },
    {
      "name": "Sofia Scatolin"
    },
    {
      "name": "Priyanka Choudhary"
    },
    {
      "name": "Natalia Vilor-Tejedor"
    },
    {
      "name": "Zhijie Liao"
    },
    {
      "name": "Silvia Alemany"
    },
    {
      "name": "Casper-Emil T Pedersen"
    },
    {
      "name": "Nora Fernandez-Jimenez"
    },
    {
      "name": "Megan L Campbell"
    },
    {
      "name": "Polina Girchenko"
    },
    {
      "name": "Eli Barthome"
    },
    {
      "name": "L Caitlin Martin"
    },
    {
      "name": "Hanna Seelemeyer"
    },
    {
      "name": "Afsheen Kumar"
    },
    {
      "name": "Alexandre Jeanne"
    },
    {
      "name": "Tarunveer S Ahluwalia"
    },
    {
      "name": "Melissa H Black"
    },
    {
      "name": "Jan K Buitelaar"
    },
    {
      "name": "Simon E Fisher"
    },
    {
      "name": "Anni Heiskala"
    },
    {
      "name": "María Hernández-Lorca"
    },
    {
      "name": "Vincent W Jaddoe"
    },
    {
      "name": "Marjo-Riitta Järvelin"
    },
    {
      "name": "Sheri-Michelle Koopowitz"
    },
    {
      "name": "Marilyn T Lake"
    },
    {
      "name": "Paul Lichtenstein"
    },
    {
      "name": "Sabrina Llop"
    },
    {
      "name": "Mannan Luo"
    },
    {
      "name": "Anni Malmberg"
    },
    {
      "name": "Sergi Marí"
    },
    {
      "name": "Albertine J Oldehinkel"
    },
    {
      "name": "Zdenka Pausova"
    },
    {
      "name": "Craig E Pennell"
    },
    {
      "name": "Robert Plomin"
    },
    {
      "name": "Ted Reichborn-Kjennerud"
    },
    {
      "name": "Sheena Reilly"
    },
    {
      "name": "Alina Rodriguez"
    },
    {
      "name": "Thomas Rolland"
    },
    {
      "name": "Angelica Ronald"
    },
    {
      "name": "Katri Räikkönen"
    },
    {
      "name": "Jean Shin"
    },
    {
      "name": "María Soler Artigas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ckk6aq1hbr5jt.bib",
  "cited_by": 0,
  "doi": "10.1038/s41562-026-02551-z",
  "fulltext_url": null,
  "id": "ckk6aq1hbr5jt",
  "issns": [
    "2397-3374",
    "2397-3374"
  ],
  "landing_url": "https://pasteur.hal.science/pasteur-05757054v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1311|Genetic Associations and Epidemiology"
    ]
  ],
  "openalex": "W7169748173",
  "pdf_url": "https://pasteur.hal.science/pasteur-05757054/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": "Nature Research [2017-....]",
  "ris": "https://research.draconitic.com/paper/ckk6aq1hbr5jt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:37Z",
      "native_id": "pasteur-05757054",
      "source": "hal",
      "url": "https://pasteur.hal.science/pasteur-05757054v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic Associations and Epidemiology",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach",
  "title_text": "Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/ckk6aq1hbr5jt",
  "venue": "Nature Human Behaviour",
  "versions": []
}