{
  "abstract": "Introduction\n\nWhile bipolar disorder is associated with significant comorbidity, little is known about the musculoskeletal health of individuals with bipolar disorder. Thus, we aimed to investigate the association between bipolar disorder and muscle strength, mass, quality and sarcopenia.Methods\n\nWomen with bipolar disorder (n = 106) were recruited from healthcare settings and age-matched to controls (n = 300), without bipolar disorder, from the Geelong Osteoporosis Study. Both groups, aged ≥ 20 years. were drawn from South-Eastern Australia. Bipolar disorder was identified using a clinical interview (SCID-I/NP). Maximum handgrip strength (HGS) was measured using a Jamar dynamometer, appendicular lean mass (ALM) using a Lunar densitometer and body mass index (BMI, kg/m²) was calculated. Foundation for the National Institute of Health (FNIH) and European Working Group on Sarcopenia in Older People (EWGSOP2) algorithms were used to determine low HGS, ALM, probable and confirmed sarcopenia. Socioeconomic status (SES) was determined and information on lifestyle obtained via questionnaire.Results\n\nHigher proportion of women with bipolar disorder met criteria for low HGS and ALM compared to those without bipolar disorder. Using FNIH and EWGSOP2 criteria, 36 (8.9%; 34 probable and 2 confirmed) and 46 (11.4%; 43 probable and 3 confirmed) women met criteria for sarcopenia, respectively. Women with bipolar disorder were twice as likely to have sarcopenia (FNIH; OR 2.24, 95% CI: 1.11-4.55 and EWGSOP2; OR 2.78, 95% CI: 1.47-5.20), independent of age, smoking, activity, alcohol, diet and SES.Conclusion\n\nThese data suggest women with bipolar disorder have an increased likelihood of sarcopenia. Replication and research into underlying mechanisms are next necessary steps.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.",
    "Barwon Health, Geelong, Victoria, Australia.",
    "Florey Institute of Neuroscience and Mental Health, Parkville, Australia.",
    "Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, Parkville, Australia.",
    "Institute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland.",
    "Institute of Clinical Medicine, Kuopio Musculoskeletal Research Unit (KMRU), University of Eastern Finland, Kuopio, Finland.",
    "Department of Medicine-Western Health, The University of Melbourne, St Albans, Victoria, Australia.",
    "School of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lana J Williams",
      "orcid": "0000-0002-1377-1272"
    },
    {
      "affs": [
        0
      ],
      "name": "Amanda L Stuart",
      "orcid": "0000-0001-8770-9511"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Michael Berk",
      "orcid": "0000-0002-5554-6946"
    },
    {
      "affs": [
        0
      ],
      "name": "Shae E Quirk",
      "orcid": "0000-0001-5375-5085"
    },
    {
      "affs": [
        0
      ],
      "name": "Emma C West",
      "orcid": "0000-0001-9559-7003"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Heli Koivumaa-Honkanen"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Risto Honkanen"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Jeremi Heikkinen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jessica A Davis"
    },
    {
      "affs": [
        0
      ],
      "name": "D Kavindi Weerasinghe",
      "orcid": "0000-0002-1050-3352"
    },
    {
      "affs": [
        0,
        1,
        6,
        7
      ],
      "name": "Julie A Pasco",
      "orcid": "0000-0002-8968-4714"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ckns8wyw0fmmk.bib",
  "cited_by": 0,
  "doi": "10.1111/bdi.70192",
  "fulltext_url": "https://europepmc.org/articles/PMC13680794",
  "id": "ckns8wyw0fmmk",
  "issns": [
    "1398-5647",
    "1399-5618"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897866",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Nutrition and Health in Aging"
    ]
  ],
  "openalex": "W7223065701",
  "pdf_url": "https://europepmc.org/articles/PMC13680794?pdf=render",
  "pmcid": "PMC13680794",
  "pmid": "42897866",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ckns8wyw0fmmk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42897866",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897866"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Nutrition and Health in Aging",
      "subfield": "physiology"
    }
  ],
  "title": "Women With Bipolar Disorder are at Increased Risk of Sarcopenia.",
  "title_text": "Women With Bipolar Disorder are at Increased Risk of Sarcopenia.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/ckns8wyw0fmmk",
  "venue": "Bipolar disorders",
  "versions": []
}