{
  "abstract": "Background\n\nFrailty represents a multidimensional vulnerability that predicts poor outcomes in cardiovascular disease. Its prognostic value in patients with severe native aortic regurgitation (AR) undergoing transcatheter aortic valve replacement (TAVR) is not well defined.Objective\n\nTo determine whether an abbreviated cumulative deficit frailty index predicts one-year all-cause mortality and to explore its interaction with N-terminal pro-B-type natriuretic peptide in this population.Methods\n\nIn this post hoc analysis of the prospective China DVD2 multicenter cohort, 298 patients with isolated severe AR who underwent TAVR were included. Frailty was assessed preprocedurally using an abbreviated 8-9-item cumulative deficit frailty index (FI) encompassing functional, cognitive, nutritional, and clinical domains. The primary endpoint was one-year all-cause mortality. The cohort-derived FI threshold for mortality was derived using time-dependent receiver operating characteristic analysis. Cox proportional hazards models adjusted for age, sex, body mass index, atrial fibrillation, and NT-proBNP were applied. Subgroup and interaction analyses were performed.Results\n\nThe cohort-derived FI threshold was 0.407, classifying 32 patients as high frailty. High-FI patients exhibited greater symptom burden, higher prevalence of atrial fibrillation, larger left atrial diameter, and elevated NT-proBNP. One-year mortality was significantly higher in the high-FI group compared with low-FI patients (15.6% vs 3.4%, P = 0.010). High FI was associated with higher one-year mortality in Model 3 (HR 4.00, 95% CI 1.18-13.50; P = 0.026). No significant multiplicative or additive interaction with NT-proBNP was observed.Conclusions\n\nAmong patients undergoing TAVR for severe native aortic regurgitation, a high FI was associated with higher one-year mortality. These findings extend prior evidence on the prognostic implications of frailty to this understudied population.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.",
    "Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qingyun Yu",
      "orcid": "0009-0003-8358-4346"
    },
    {
      "affs": [
        1
      ],
      "name": "Qingan Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zaihua Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Huang",
      "orcid": "0000-0003-0686-6318"
    },
    {
      "affs": [
        0
      ],
      "name": "Ren Gong"
    },
    {
      "affs": [
        1
      ],
      "name": "Haiyan Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yongjian Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanqing Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ckp4xcbv6ysf4.bib",
  "cited_by": 0,
  "doi": "10.2147/cia.s643768",
  "fulltext_url": "https://europepmc.org/articles/PMC13726637",
  "id": "ckp4xcbv6ysf4",
  "issns": [
    "1176-9092",
    "1178-1998"
  ],
  "landing_url": "https://europepmc.org/article/MED/42974471",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7224311806",
  "pdf_url": "https://europepmc.org/articles/PMC13726637?pdf=render",
  "pmcid": "PMC13726637",
  "pmid": "42974471",
  "published": "2026-10-29",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/ckp4xcbv6ysf4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974471",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974471"
    },
    {
      "first_seen": "2026-11-05T12:22:56Z",
      "native_id": "PMC13726637",
      "source": "pmc",
      "url": "https://doi.org/10.2147/cia.s643768"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Prognostic Value of the Frailty Index in Patients with Severe Aortic Regurgitation Undergoing Transcatheter Aortic Valve Replacement.",
  "title_text": "Prognostic Value of the Frailty Index in Patients with Severe Aortic Regurgitation Undergoing Transcatheter Aortic Valve Replacement.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:32Z",
  "url": "https://research.draconitic.com/paper/ckp4xcbv6ysf4",
  "venue": "Clinical interventions in aging",
  "versions": []
}