{
  "abstract": "We aimed to unravel the efficacy of thoraco-laparoscopic combined McKeown esophagectomy for esophageal cancer and its impact on inflammatory response and coagulation function. We retrospectively analyzed 108 esophageal cancer patients, divided into thoraco-laparoscopic (TLE) and open esophagectomy (OE) groups. Observed indicators included surgical parameters (operative time, blood loss, ICU and hospital stays), inflammatory markers [white blood cell (WBC), neutrophil percentage (NEUT%), lymphocyte percentage (LYMPH%), platelet (PLT)], coagulation profiles [prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D)], complications, and 1-year disease-free survival. The TLE group demonstrated reduced intraoperative blood loss, shorter ICU and total hospital stays, and lower complication rates than the OE group (P<0.05). Postoperative inflammatory and coagulation profiles also differed, with TLE showing lower WBC (11.35±2.58 vs 12.48±2.41 109/L), NEUT% (72.28±6.62 vs 79.41±6.94%), PLT (233.87±19.62 vs 245.56±22.79 109/L), PT (11.41±0.79 vs 12.00±1.05 s), APTT (26.70±3.60 vs 28.83±3.08 s), and INR (0.90±0.07 vs 0.95±0.10), but higher LYMPH% (21.80±4.06 vs 19.52±4.16 %), D-D (348.89±37.92 vs 315.27±36.74 μg/L), and FIB (3.95±0.56 vs 3.71±0.51 g/L) levels than the OE group (P<0.05). TLE was an effective and reliable approach associated with fewer complications and comparable one-year oncologic outcomes to open surgery, though its effects on coagulation parameters warrant closer clinical monitoring.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Thoracic Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
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        0
      ],
      "name": "Zhengqiao Wang",
      "orcid": "0009-0004-1027-0191"
    },
    {
      "affs": [
        0
      ],
      "name": "Renquan Zhang",
      "orcid": "0009-0003-4457-6829"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ckr3kkvqv1k4r.bib",
  "cited_by": 0,
  "doi": "10.1590/1414-431x2026e15544",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721996/?tool=EBI",
  "id": "ckr3kkvqv1k4r",
  "issns": [
    "0100-879X",
    "1414-431X"
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  "landing_url": "https://europepmc.org/article/PMC/PMC13721996",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
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      "openalex",
      "2746|Esophageal Cancer Research and Treatment"
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  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721996/pdf/?tool=EBI",
  "pmcid": "PMC13721996",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Associação Brasileira de Divulgação Científica",
  "ris": "https://research.draconitic.com/paper/ckr3kkvqv1k4r.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13721996",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13721996"
    },
    {
      "first_seen": "2026-11-03T12:22:35Z",
      "native_id": "PMC13721996",
      "source": "pmc",
      "url": "https://doi.org/10.1590/1414-431x2026e15544"
    },
    {
      "first_seen": "2026-11-03T14:21:30Z",
      "native_id": "1bd8562d8da249ffab2659f8b6a9c91d",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Esophageal Cancer Research and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Thoraco-laparoscopic versus open McKeown esophagectomy for esophageal cancer: comparative outcomes on inflammatory response and coagulation function",
  "title_text": "Thoraco-laparoscopic versus open McKeown esophagectomy for esophageal cancer: comparative outcomes on inflammatory response and coagulation function",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T14:20:26Z",
  "url": "https://research.draconitic.com/paper/ckr3kkvqv1k4r",
  "venue": "Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas",
  "versions": []
}