{
  "abstract": "Here we report that Dectin-1-stimulated dendritic cells (DCs) induce unique IL-10-producing T cells with strong regulatory function during fungal infection or experimental asthma. These T cells, which we call Dect-10 T cells, are induced by DC-initiated signaling that sets in motion two complementary mechanisms of IL-10-producing T cell differentiation. The first involves induction of nascent Dect-10 T cell IL-4 synthesis and attendant GATA3 production, the latter being a factor that exerts canonical and epigenetic transcriptional function at separate IL-10 promoter sites. The second involves TGFβ superfamily signaling associated with induction of glutaminolysis and generation of alpha-ketoglutarate, a factor that induces rapamycin-sensitive TORC1 activation; in turn, such activation causes the translation of the LIP isoform of C/EBPβ and the formation of a CREB1-LIP complex that binds to adjacent sites on the IL-10 promoter to facilitate the transactivation of the IL10 gene. Dect-10 T cell regulatory function is manifested through its capacity to down-regulate normally protective immune responses to hyphal C. albicans renal infection. In addition, Dect-10 T cells, in accord with their IL-4-dependent genesis, suppress dust mite-induced experimental asthma.",
  "abstract_shown": true,
  "affiliations": [
    "Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.",
    "Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.",
    "Department of Immunology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan.",
    "Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Masaki Tajima",
      "orcid": "0000-0003-3407-0229"
    },
    {
      "affs": [
        0
      ],
      "name": "Ivan J Fuss"
    },
    {
      "affs": [
        2
      ],
      "name": "Naoko Ikuta"
    },
    {
      "affs": [
        0
      ],
      "name": "Liming Mao"
    },
    {
      "affs": [
        3
      ],
      "name": "Timothy G Myers",
      "orcid": "0000-0002-7059-5906"
    },
    {
      "affs": [
        3
      ],
      "name": "Paul J Gardina"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsushi Kitani",
      "orcid": "0000-0001-7628-1716"
    },
    {
      "affs": [
        0
      ],
      "name": "Warren Strober"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cm7w28smwfq35.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198447",
  "fulltext_url": "https://europepmc.org/articles/PMC13664842",
  "id": "cm7w28smwfq35",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883696",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7214043822",
  "pdf_url": "https://europepmc.org/articles/PMC13664842?pdf=render",
  "pmcid": "PMC13664842",
  "pmid": "42883696",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cm7w28smwfq35.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883696",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883696"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Glutaminolysis and mTOR-C/EBPβ Signaling Drives the Differentiation of Novel IL-10-Producing Regulatory T Cells.",
  "title_text": "Glutaminolysis and mTOR-C/EBPβ Signaling Drives the Differentiation of Novel IL-10-Producing Regulatory T Cells.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/cm7w28smwfq35",
  "venue": "International journal of molecular sciences",
  "versions": []
}