{
  "abstract": "Background: Postoperative sepsis arises from a dysregulated host response to infection following surgical stress. Current non-specific biomarkers offer insufficient predictive value, highlighting the need to identify molecular signatures that may facilitate earlier recognition of postoperative sepsis while providing insight into the underlying immune regulatory mechanisms.\n\nMethods: Transcriptomic datasets comprising postoperative septic and non-septic surgical cohorts, together with independent cohorts of sepsis and non-infectious systemic inflammation, were analyzed using Weighted Gene Co-expression Network Analysis and machine-learning approaches to identify hub genes. A diagnostic nomogram was constructed and validated across independent cohorts. A murine postoperative endotoxemia model (tibial fracture surgery followed by LPS challenge) was used for in vivo validation. Single-cell RNA sequencing analysis and LAIR1 antibody blockade were performed to assess cellular and functional relevance.\n\nResults: A four-gene signature comprising LAIR1, PLAC8, ACSS2, and PCOLCE2 was identified. The resulting model achieved AUCs of 0.865 in GSE131761, 0.965 in GSE74224, 0.827 in E-MTAB-1548, 0.929 in GSE65682, and 0.997 in GSE77167. Among the four genes, LAIR1 showed the most sustained upregulation in peripheral blood and multiple organs during postoperative endotoxemia. Single-cell analysis identified monocytes as the predominant circulating source of LAIR1. LAIR1 blockade increased systemic cytokine release, aggravated multiorgan injury, and reduced survival.\n\nConclusions: The four-gene signature reproducibly distinguished sepsis from infection-negative systemic inflammation across surgical and broader ICU cohorts. LAIR1 exhibited monocyte-enriched expression and a protective immunoregulatory role in postoperative endotoxemia, supporting its relevance to immune dysregulation of sepsis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, The Second Xiangya Hospital, Central South University",
    "Anesthesiology Research Institute, Central South University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Tao Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yang Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Liyun Zeng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xuemei Miao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu Peng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jingying Yu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiaying Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Qian Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ziyan Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ruping Dai"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hui Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmdb2esydrz71.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1931628",
  "fulltext_url": "https://europepmc.org/articles/PMC13713299",
  "id": "cmdb2esydrz71",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1931628/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7221778290",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1931628/pdf",
  "pmcid": "PMC13713299",
  "pmid": "42952602",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cmdb2esydrz71.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1931628",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1931628/full"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42952602",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952602"
    },
    {
      "first_seen": "2026-10-31T12:23:52Z",
      "native_id": "PMC13713299",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1931628"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Integrated transcriptomic and functional analyses identify LAIR1 as a key immunoregulatory molecule in postoperative sepsis",
  "title_text": "Integrated transcriptomic and functional analyses identify LAIR1 as a key immunoregulatory molecule in postoperative sepsis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:59Z",
  "url": "https://research.draconitic.com/paper/cmdb2esydrz71",
  "venue": "Frontiers in Immunology",
  "versions": []
}