{
  "abstract": "Objective: To investigate the characteristics of pandemic-related stress symptoms among frontline healthcare workers involved in COVID-19 prevention and control, as well as the roles of overgeneralized autobiographical memory (OGM) and inflammatory markers in these symptoms.\n\nMethods: Using convenience sampling, 52 frontline healthcare workers (exposure group) and 55 non-frontline healthcare workers (control group) who participated in COVID-19 prevention and control efforts at the Guannan Campus of Lianyungang First People’s Hospital between March 2020 and March were selected.Assessments were conducted using the Posttraumatic Stress Disorder Checklist (PCL-C), the Autobiographical Memory Test (AMT), and the Childhood Trauma Questionnaire (CTQ), and serum levels of IL-1β, IL-2, IL-6, IL-8, IL-18, and C-reactive protein (CRP) were measured.Statistical analyses were performed using the Mann-Whitney U test, Spearman’s rank correlation, and bootstrap stratified regression analysis.\n\nResults: In the exposure group, significant differences compared to the control group were observed in PCL-C avoidance (Z = −1.984, P = 0.047), hypervigilance (Z = −2.020, P = 0.043), OGM total score (Z = −4.379, P &lt; 0.001), IL-1β (Z = −2.029, P = 0.042), and CRP (Z = −2.605, P = 0.009), but not for the PCL-C total score, re-experiencing dimension, or IL-18. Both PCL-C avoidance and vigilance were positively correlated with the OGM total score (r = 0.447, P &lt; 0.01) and CRP (r = 0.698, P &lt; 0.01), but not with IL-1β (P &gt; 0.05). Stratified regression showed significant associations of OGM total score and CRP with PCL-C vigilance (β = 0.299, P = 0.005; β = 0.587, P &lt; 0.001) and avoidance (β = 0.302, P = 0.006; β = 0.660, P &lt; 0.001), while IL-1β correlation was not significant (P &gt; 0.05).\n\nConclusion: Frontline healthcare workers during the COVID-19 pandemic showed higher stress symptoms and elevated inflammatory markers, OGM and CRP, compared to a control group. OGM and CRP were linked to pandemic-related stress, while IL-1β, although elevated, lacked independent predictive power. CRP showed the strongest correlation with stress symptoms, suggesting it could be a key biological marker for understanding pandemic-related stress.",
  "abstract_shown": true,
  "affiliations": [
    "Suzhou Guangji Hospital, Affiliated Guangji Hospital of Soochow University",
    "Suzhou Fifth People’s Hospital",
    "Guannan County First People’s Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuangshuang Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianping Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yangyang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yansong Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmdsdg2adzfex.bib",
  "cited_by": 0,
  "doi": "10.3389/fpsyt.2026.1990292",
  "fulltext_url": null,
  "id": "cmdsdg2adzfex",
  "issns": [
    "1664-0640"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1990292/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cmdsdg2adzfex.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:21:23Z",
      "native_id": "10.3389/fpsyt.2026.1990292",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1990292/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-0640",
      "subfield": "psychiatry"
    }
  ],
  "title": "The role of overgeneralized autobiographical memories and inflammatory markers in stress symptoms associated with the COVID-19 pandemic",
  "title_text": "The role of overgeneralized autobiographical memories and inflammatory markers in stress symptoms associated with the COVID-19 pandemic",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T00:23:06Z",
  "url": "https://research.draconitic.com/paper/cmdsdg2adzfex",
  "venue": "Frontiers in Psychiatry",
  "versions": []
}