{
  "abstract": "Background: Endoscopic healing is an established treatment target for ulcerative colitis (UC). We have recently validated the Milan ultrasound criteria (MUC) to assess endoscopic activity in UC; a MUC score > 6.2 is a valid cut-off to discriminate endoscopic activity (Mayo endoscopic subscore > 1). Objective: The aim of this study was to assess the predictive value of MUC on disease course in a prospective cohort of UC patients. Methods: UC patients regardless of disease activity and current therapy, underwent colonoscopy and bowel ultrasound (US) at baseline in a blinded fashion. Correlations between baseline MUC and Mayo endoscopic subscore were assessed using Spearman's rank correlation. UC-related negative course (defined as the need for corticosteroids, or treatment escalation, or hospitalization, or need for colectomy: a composite outcome) over a median 20 months follow-up, was investigated using the Kaplan-Meier method and Cox regression analysis. Results: 98 UC patients were followed up for a median time of 1.6 years (IQR 0.9¬2.7). Milan ultrasound criteria and Mayo endoscopic subscore significantly correlated at baseline (ρ = 0.653; p < 0.001). 70 patients (71%) had negative disease course during the follow-up period. Milan ultrasound criteria > 6.2 at baseline was statistically significantly associated with negative disease course (HR: 3.87, 95% CI: 2.25-6.64, p < 0.001). Kaplan-Meier analyses drawed a statistically significantly lower cumulative probability of treatment escalation, need of corticosteroids, hospitalization and colectomy, among patients who had MUC ≤ 6.2 at baseline as compared to patients with MUC > 6.2 (p < 0.05 for all outcomes). Conclusion: we have demonstrated for the first time the value of bowel US and an US score in predicting disease course in UC. Milan ultrasound criteria, a validated US-based score, predicts disease course in UC. Milan ultrasound criteria ≤ 6.2 may be the new treatment target to achieve to reduce the risk of worse outcomes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Mariangela Allocca"
    },
    {
      "name": "Cecilia Dell'Avalle"
    },
    {
      "name": "Vincenzo Craviotto"
    },
    {
      "name": "Federica Furfaro"
    },
    {
      "name": "Alessandra Zilli"
    },
    {
      "name": "Ferdinando d'Amico"
    },
    {
      "name": "Stefanos Bonovas"
    },
    {
      "name": "Laurent Peyrin‐biroulet"
    },
    {
      "name": "Gionata Fiorino"
    },
    {
      "name": "Silvio Danese"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmk01m76dm5v5.bib",
  "cited_by": 62,
  "doi": "10.1002/ueg2.12206",
  "fulltext_url": null,
  "id": "cmk01m76dm5v5",
  "issns": [
    "2050-6406",
    "2050-6414"
  ],
  "landing_url": "https://hal.univ-lorraine.fr/hal-04168249v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W4214817863",
  "pdf_url": "https://hal.univ-lorraine.fr/hal-04168249/document",
  "pmcid": null,
  "pmid": "35233934",
  "published": "2026-09-17",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/cmk01m76dm5v5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "hal-04168249",
      "source": "hal",
      "url": "https://hal.univ-lorraine.fr/hal-04168249v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Predictive value of Milan ultrasound criteria in ulcerative colitis: A prospective observational cohort study",
  "title_text": "Predictive value of Milan ultrasound criteria in ulcerative colitis: A prospective observational cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/cmk01m76dm5v5",
  "venue": "United European Gastroenterology Journal",
  "versions": []
}