{
  "abstract": "Herein, we report a stereoselective Morita-Baylis-Hillman protocol to access allylic γ-imino α-trifluoromethyl alcohol adducts. The reaction proceeds under mild and tunable conditions, enabling diastereodivergent access to the two possible stereoisomers through modulation of the Lewis base and additives. The synthetic interest of the resulting compounds as precursors of medicinally relevant fluorinated scaffolds has been demonstrated. A proposal for the reaction mechanism and the stereochemical induction has also been made.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, Alicante03080, Spain.",
    "Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, Apdo. 99, Alicante03080, Spain."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ana Sirvent",
      "orcid": "0000-0001-6127-4011"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ester Blanco-López"
    },
    {
      "affs": [
        1
      ],
      "name": "Carmen Nájera",
      "orcid": "0000-0003-0063-5527"
    },
    {
      "affs": [
        1
      ],
      "name": "Miguel Yus",
      "orcid": "0000-0003-1088-6944"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Francisco Foubelo",
      "orcid": "0000-0001-7847-8440"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "José M Sansano",
      "orcid": "0000-0002-5536-2717"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "María de Gracia Retamosa",
      "orcid": "0000-0003-1131-5916"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmkbr83m71sa1.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.joc.6c02039",
  "fulltext_url": "https://europepmc.org/articles/PMC13621807",
  "id": "cmkbr83m71sa1",
  "issns": [
    "0022-3263",
    "1520-6904"
  ],
  "landing_url": "https://europepmc.org/article/MED/42917426",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7212361442",
  "pdf_url": "https://europepmc.org/articles/PMC13621807?pdf=render",
  "pmcid": "PMC13621807",
  "pmid": "42917426",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cmkbr83m71sa1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42917426",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42917426"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Diastereodivergent Morita-Baylis-Hillman Reaction of α,β-Unsaturated N-tert-Butanesulfinyl Imines and Trifluoromethyl Ketones.",
  "title_text": "Diastereodivergent Morita-Baylis-Hillman Reaction of α,β-Unsaturated N-tert-Butanesulfinyl Imines and Trifluoromethyl Ketones.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/cmkbr83m71sa1",
  "venue": "The Journal of organic chemistry",
  "versions": []
}