{
  "abstract": "Endoplasmic reticulum (ER) mitigates stress typically through unfolded protein response (UPR) and ER-associated degradation (ERAD) pathways, yet post-transcriptional regulation of ER stress remains poorly defined. N6-methyladenosine (m6A) modification, predominantly enriched near stop codons, can govern mRNA fates via P-bodies or stress granules in stress conditions. m6A also occurs within coding sequences (CDS-m6A), but its role remains unappreciated in plants. Here we demonstrate that m6A ablation sensitizes Arabidopsis ER stress despite normal UPR and ERAD activities. Mechanistically, CDS-m6A colocalizes with ribosome stalling sites and directs co-translational RNA decay (CTRD). Under stress, activation of m6A-triggered CTRD accelerates clearance of ER-engaged transcripts, thereby alleviating translational overload. During Geminivirus infection, which increases translational demand on ER, m6A-triggered CTRD also targets viral RNAs, restricting their accumulation, translation and disease progression. Thus, CDS-m6A functions as a pivotal regulator of ER-linked RNA surveillance, establishing an organelle-specific mechanism that integrates RNA stability, protein homeostasis, and antiviral defense.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.",
    "Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.",
    "Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.",
    "These authors contributed equally.",
    "Xenohelix Research Institute, Incheon 21984, Republic of Korea",
    "CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China",
    "Department of Medical Physiology, Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807, USA",
    "Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.",
    "Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.",
    "Former: Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.",
    "Institute of Emerging Agricultural Technology, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, 518107, China.",
    "Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, 518107, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Songxiao Zhong"
    },
    {
      "affs": [
        0,
        4,
        3
      ],
      "name": "Taerin Oh"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Xindi Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinming Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Suk Won Choi"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Chuyun Gao"
    },
    {
      "affs": [
        6
      ],
      "name": "Xu Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Dong"
    },
    {
      "affs": [
        1,
        2,
        7,
        8
      ],
      "name": "Chuan He"
    },
    {
      "affs": [
        9,
        10,
        11
      ],
      "name": "Xiuren Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmsh1pcwa0cbc.bib",
  "cited_by": 2,
  "doi": "10.1038/s41477-026-02299-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13717571/",
  "id": "cmsh1pcwa0cbc",
  "issns": [
    "2055-0278"
  ],
  "landing_url": "https://doi.org/10.1038/s41477-026-02299-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|RNA modifications and cancer"
    ]
  ],
  "openalex": "W7160607136",
  "pdf_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13717571/pdf/nihms-2215862.pdf",
  "pmcid": "PMC13717571",
  "pmid": "42103909",
  "published": "2026-05-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cmsh1pcwa0cbc.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:21:52Z",
      "native_id": "PMC13717571",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41477-026-02299-4"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|RNA modifications and cancer",
      "subfield": "molecular-biology"
    }
  ],
  "title": "CDS-localized m6A drives co-translational RNA decay to relieve biotic and abiotic endoplasmic reticulum stresses",
  "title_text": "CDS-localized m6A drives co-translational RNA decay to relieve biotic and abiotic endoplasmic reticulum stresses",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:52Z",
  "url": "https://research.draconitic.com/paper/cmsh1pcwa0cbc",
  "venue": "Nature plants",
  "versions": []
}