{
  "abstract": "Background\n\nThe safety of statin use during pregnancy remains controversial. We aimed to evaluate the association between prenatal statin exposure and pregnancy outcomes in Asian women, including low birth weight, preterm birth, and congenital anomalies.Methods\n\nWe conducted a PRISMA-compliant systematic review and meta-analysis of studies in Asian populations evaluating prenatal statin exposure. PubMed, Embase, the Cochrane Library, Web of Science, and trial registries were searched through January 31, 2026. Eligible randomized and observational studies included Asian populations and reported low birth weight, preterm birth, or congenital anomalies. Adjusted risk ratios were pooled using random-effects inverse-variance models, and risk of bias was assessed with standard tools.Results\n\nThree nationwide observational cohort studies from Taiwan and South Korea were included in the quantitative synthesis, and one Indonesian randomized trial of pravastatin for preeclampsia prevention was reviewed qualitatively. Prenatal statin exposure was not associated with congenital anomalies (RR, 0.98; 95% CI, 0.89-1.08; I² = 0%), but was associated with low birth weight (RR, 1.27; 95% CI, 1.07-1.49; I² = 49%). The association with preterm birth was not statistically significant (RR, 1.24; 95% CI, 0.95-1.62; I² = 87%). Sensitivity analyses restricted to exposed versus unexposed comparisons yielded similar conclusions.Conclusions\n\nThe available Asian evidence, largely derived from nationwide East Asian cohorts, suggests no clear association between prenatal statin exposure or continuation and congenital anomalies. A modest association with low birth weight was observed, whereas evidence for preterm birth remained inconclusive. The low-birth-weight finding should be interpreted cautiously because of residual confounding, comparator heterogeneity, prematurity-related low birth weight, and pharmacological heterogeneity across statins.Systematic review registration\n\nPROSPERO CRD420251235975.",
  "abstract_shown": true,
  "affiliations": [
    "Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.",
    "Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. chzheng@zju.edu.cn.",
    "Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. chenyue0111@zju.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuya Ye"
    },
    {
      "affs": [
        0
      ],
      "name": "Fan Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongli Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Meng Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Caihong Zheng"
    },
    {
      "affs": [
        2
      ],
      "name": "Yue Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmwavcb98ya65.bib",
  "cited_by": 0,
  "doi": "10.1186/s12887-026-07379-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13685195",
  "id": "cmwavcb98ya65",
  "issns": [
    "1471-2431"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902252",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RJ1-570"
    ],
    [
      "openalex",
      "2739|Pregnancy and Medication Impact"
    ]
  ],
  "openalex": "W7170208557",
  "pdf_url": "https://europepmc.org/articles/PMC13685195?pdf=render",
  "pmcid": "PMC13685195",
  "pmid": "42902252",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/cmwavcb98ya65.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42902252",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902252"
    },
    {
      "first_seen": "2026-10-30T13:46:26Z",
      "native_id": "bdeffe7b7ca9401b9118f8557682ee3f",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12887-026-07379-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Pregnancy and Medication Impact",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Prenatal statin exposure and adverse birth outcomes in Asian women: a systematic review and meta-analysis.",
  "title_text": "Prenatal statin exposure and adverse birth outcomes in Asian women: a systematic review and meta-analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:26Z",
  "url": "https://research.draconitic.com/paper/cmwavcb98ya65",
  "venue": "BMC pediatrics",
  "versions": []
}