{
  "abstract": "Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by a profound dysregulation of immune-epithelial crosstalk. Beyond canonical ATP production, mitochondria function as essential intracellular immunometabolic hubs embedded within the cytokine-driven network of psoriatic lesions. Within this inflammatory niche, keratinocytes and immune cells undergo structural and metabolic adaptations. Aberrant mitochondrial stress byproducts—including mitochondrial reactive oxygen species (mtROS), oxidized mitochondrial DNA (mtDNA), and metabolic intermediates—act as secondary amplifiers that reinforce innate immune sensing and adaptive T cell responses, thereby sustaining a localized inflammatory loop. Here, we propose that targeting mitochondrial pathways provides a novel, stage-dependent therapeutic framework: stabilizing mitochondrial dynamics during acute flare-ups to halt inflammation, disrupting tissue-resident memory T (T RM ) cell metabolic fitness during the stable phase to avert relapse, and restoring regulatory T (Treg) cell oxidative phosphorylation (OXPHOS) during regression to re-establish peripheral immune tolerance. Transitioning from broad immunosuppression to precision mitochondrial modulation offers a promising paradigm for cell-specific psoriasis interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, The Hospital of China Medical University",
    "Key Laboratory of Immunodermatology, Ministry of Education, and National Health Commission; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Fangru Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yaoxing Guo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xin Tong"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiangnan Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yingdi Jiao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Renjie Han"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hongduo Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ruiqun Qi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmxte2whymdtq.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1991331",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1991331/full",
  "id": "cmxte2whymdtq",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1991331/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC581-607"
    ],
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
    ]
  ],
  "openalex": "W7223364973",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1991331/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cmxte2whymdtq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1991331",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1991331/full"
    },
    {
      "first_seen": "2026-10-30T13:43:52Z",
      "native_id": "2572d5d485284a028b41255cfad24734",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fimmu.2026.1991331"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Psoriasis: Treatment and Pathogenesis",
      "subfield": "immunology"
    }
  ],
  "title": "Mitochondria as immunometabolic hubs in psoriasis: pathogenic mechanisms and therapeutic prospects",
  "title_text": "Mitochondria as immunometabolic hubs in psoriasis: pathogenic mechanisms and therapeutic prospects",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:52Z",
  "url": "https://research.draconitic.com/paper/cmxte2whymdtq",
  "venue": "Frontiers in Immunology",
  "versions": []
}