{
  "abstract": "Hodgkin lymphoma (HL) is a B-cell neoplasm with a cure rate of 90%. Previous data on late morbidity in patients with HL cover the era of older treatment modalities. This real-world study consisted of 2912 patients diagnosed with HL between 2000 and 2019 in Finland and aimed to clarify the incidence of late-onset cardiopulmonary morbidity compared to matched controls. Patient data were collected from four nationwide Finnish healthcare registries. We reported a higher occurrence of coronary artery disease in patients aged < 50 years at diagnosis than in controls (RR 3.80 (2.16-6.74), p < 0001). Additionally, a higher incidence of both heart failure (RR 1.68 (1.28-2.21), p < 0.001) and valvular heart disease (RR 1.80 (1.17-2.78), p = 0.006) was detected in patients aged ≥ 50 years at diagnosis than in the controls. Remarkably, in the < 50 years age group, the incidences of pneumonia (RR 4.89 (3.58-6.71), p < 0.001) and pulmonary embolism (RR 7.78 (2.75-21.95), p < 0.001) were higher than those in the control group. In conclusion, with the current treatment modalities, late cardiopulmonary morbidity in long-term survivors remains a great challenge. A strategy for primary prevention and early detection of late toxicity remains crucial and a critical evaluation of current treatment practices is warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Oncology, Faculty of Health Medicine, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. nhannuks@student.uef.fi.",
    "Oncology, Faculty of Health Medicine, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.",
    "Department of Oncology, Kuopio University Hospital, Kuopio, Finland.",
    "Medaffcon Oy, Espoo, Finland.",
    "Department of Oncology, Department of Radiotherapy, Kuopio University Hospital, Kuopio, Finland.",
    "Cancer Centre, Oulu University Hospital, Oulu, Finland.",
    "Takeda Oy, Helsinki, Finland.",
    "Department of Medicine, Kuopio University Hospital, Kuopio, Finland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Noora Hannuksela",
      "orcid": "0009-0000-0894-6333"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Outi Kuittinen"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Aino Rönkä"
    },
    {
      "affs": [
        3
      ],
      "name": "Anna Anttalainen"
    },
    {
      "affs": [
        3
      ],
      "name": "Liisa Ukkola-Vuoti"
    },
    {
      "affs": [
        3
      ],
      "name": "Iiro Toppila"
    },
    {
      "affs": [
        3
      ],
      "name": "Johanna Vikkula"
    },
    {
      "affs": [
        4
      ],
      "name": "Jan Seppälä"
    },
    {
      "affs": [
        2
      ],
      "name": "Kristiina Vuolukka"
    },
    {
      "affs": [
        2
      ],
      "name": "Katja Marin"
    },
    {
      "affs": [
        5
      ],
      "name": "Hanne Kuitunen"
    },
    {
      "affs": [
        6
      ],
      "name": "Tatu Miettinen"
    },
    {
      "affs": [
        7
      ],
      "name": "Anu Partanen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cmyp0av4rz13x.bib",
  "cited_by": 0,
  "doi": "10.1007/s00277-026-07193-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13677623",
  "id": "cmyp0av4rz13x",
  "issns": [
    "0939-5555",
    "1432-0584"
  ],
  "landing_url": "https://europepmc.org/article/MED/42894041",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC31-1245"
    ],
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7170052923",
  "pdf_url": "https://europepmc.org/articles/PMC13677623?pdf=render",
  "pmcid": "PMC13677623",
  "pmid": "42894041",
  "published": "2026-07-01",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/cmyp0av4rz13x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42894041",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894041"
    },
    {
      "first_seen": "2026-10-30T13:45:38Z",
      "native_id": "c02d489cde7e462ea2aefd9029e52e30",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s00277-026-07193-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study.",
  "title_text": "Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:38Z",
  "url": "https://research.draconitic.com/paper/cmyp0av4rz13x",
  "venue": "Annals of hematology",
  "versions": []
}