{
  "abstract": "Background: Poly‐L‐lactic acid (PLLA) is an established soft‐tissue filler for correcting nasolabial folds (NLFs), offering durable results and high patient satisfaction. This study evaluated the efficacy and safety of a novel PLLA filler (HYZ) for this indication.\n\nMethods: In this prospective, multicenter, randomized, double‐blind, non‐inferiority clinical trial, 176 subjects were randomly assigned to two groups, were randomized to receive three sessions of either HYZ (experimental group) or Löviselle (control group) injections at 3‐week intervals. Efficacy was assessed using the Global Aesthetic Improvement Scale (GAIS) and the Wrinkle Severity Rating Score (WSRS). Safety was evaluated based on adverse events (AEs).\n\nResults: From baseline to Week 54, the HYZ group consistently showed higher WSRS response rates than the control group. At Week 54, the response rate was significantly higher in the HYZ group (54.02% vs. 36.36%, p < 0.05), meeting the predefined non‐inferiority margin (Δ = −10%). No significant between‐group differences were observed in GAIS response rates. The incidence of adverse events was comparable between the two groups.\n\nConclusion: The novel PLLA filler (HYZ) was non‐inferior to the established product Löviselle in both efficacy and safety for NLF correction. These findings provide new clinical evidence supporting the continued development and optimization of PLLA‐based fillers.",
  "abstract_shown": true,
  "affiliations": [
    "Sihuan Pharmaceutical Holdings Group Ltd. Beijing China",
    "Meiyan Space, Sihuan Pharmaceutical Holdings Group Ltd. Beijing China",
    "Department of Plastic Surgery China‐Japan Union Hospital of Jilin University Jilin China",
    "Department of Medical Cosmetology Yanbian University Hospital Jilin China",
    "Department of Plastic Surgery, Shulan (Hangzhou) Hospital, Shulan International Medical College Zhejiang Shuren University Hangzhou China",
    "Department of Otolaryngology Tonghua Central Hospital Tonghua China",
    "Beijing Aohe Pharmaceutical Research Institute Co., Ltd. Beijing China",
    "Department of Cosmetic Dermatology Beijing MYLIKE Medical Cosmetic Hospital Beijing China",
    "Department of Cosmetic Dermatology Shenzhen Xi'en Medical Cosmetic Clinic Shenzhen China",
    "Department of Cosmetic Dermatology Anhui Haobai Medical Cosmetic Clinic Hefei China",
    "Department of Cosmetic Dermatology Hainan Yishangmei Medical Cosmetic Clinic Haikou China",
    "Department of Cosmetic Dermatology Wenzhou Peace International Hospital Wenzhou China",
    "Department of Cosmetic Dermatology Qingdao Doctor Medical Cosmetic Hospital Qingdao China",
    "Department of Cosmetic Dermatology Qingdao LORD Medical Cosmetic Hospital Qingdao China",
    "Department of Cosmetic Dermatology Shenzhen MYLIKE Medical Cosmetic Hospital Shenzhen China",
    "Department of Cosmetic Dermatology Sichuan Huamei Zixin Plastic Surgery Hospital Chengdu China",
    "Department of Cosmetic Dermatology Chongqing Xinfu Medical Cosmetic Clinic Chongqing China",
    "Hunan University of Medicine Huaihua China",
    "School of Pharmaceutical Sciences Sun Yat‐Sen University Guangzhou China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhanhong Li",
      "orcid": "0000-0002-7287-7245"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jingfang Sun"
    },
    {
      "affs": [
        2
      ],
      "name": "Lianbo Zhang",
      "orcid": "0000-0003-2020-1355"
    },
    {
      "affs": [
        3
      ],
      "name": "Aili Cui"
    },
    {
      "affs": [
        4
      ],
      "name": "Sha Huang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yaowu Dong"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Haibo Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongmei Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoyi Qiu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiuting Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiang Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Yuan"
    },
    {
      "affs": [
        7
      ],
      "name": "Yanqi Ye"
    },
    {
      "affs": [
        8
      ],
      "name": "Xiao Wang"
    },
    {
      "affs": [
        9
      ],
      "name": "Liang Chen"
    },
    {
      "affs": [
        10
      ],
      "name": "Chongguo Liang",
      "orcid": "0009-0007-4871-2081"
    },
    {
      "affs": [
        11
      ],
      "name": "Liwei Wu"
    },
    {
      "affs": [
        12
      ],
      "name": "Junlong Guo"
    },
    {
      "affs": [
        13
      ],
      "name": "Xiaojuan Zhang"
    },
    {
      "affs": [
        14
      ],
      "name": "Wenting Chen",
      "orcid": "0009-0008-9785-4235"
    },
    {
      "affs": [
        15
      ],
      "name": "Ping Yu"
    },
    {
      "affs": [
        16
      ],
      "name": "Jing Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Fengsheng Che"
    },
    {
      "affs": [
        0,
        17,
        18
      ],
      "name": "Qiong Meng",
      "orcid": "0000-0003-0240-0879"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cn0p2pjg5zcq3.bib",
  "cited_by": 0,
  "doi": "10.1111/jocd.71260",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696741/",
  "id": "cn0p2pjg5zcq3",
  "issns": [
    "1473-2130",
    "1473-2165"
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  "landing_url": "https://doi.org/10.1111/jocd.71260",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
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      "2708|Facial Rejuvenation and Surgery Techniques"
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  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13696741/pdf/?tool=EBI",
  "pmcid": "PMC13696741",
  "pmid": null,
  "published": "2026-10-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cn0p2pjg5zcq3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
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  ],
  "title": "Safety and Efficacy of Poly‐L‐Lactic Acid Filler (HYZ vs. Löviselle) Injection for Nasolabial Fold Correction: A Double‐Blind, Non‐Inferiority, Randomized, Controlled Trial",
  "title_text": "Safety and Efficacy of Poly‐L‐Lactic Acid Filler (HYZ vs. Löviselle) Injection for Nasolabial Fold Correction: A Double‐Blind, Non‐Inferiority, Randomized, Controlled Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:01Z",
  "url": "https://research.draconitic.com/paper/cn0p2pjg5zcq3",
  "venue": "Journal of Cosmetic Dermatology",
  "versions": []
}